Relationships between insulin-like growth factor-I (IGF-I) and OPG, RANKL, bone mineral density in healthy Chinese women
Relationships between insulin-like growth factor-I (IGF-I) and OPG, RANKL, bone mineral density in healthy Chinese women
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中国健康女性胰岛素样生长因子-I（IGF-I）与OPG、RANKL、骨密度的关系
DOI：
10.1007/s00198-007-0440-y
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发表时间：
2008-02
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
摘要血清IGF-I水平与OPG和OPG/RANKL比值呈负相关，与RANKL呈正相关。 IGF-I 最高五分位数的血清 OPG 水平显着低于最低五分位数。我们得出结论，IGF-I 对骨重塑的作用可能是由 OPG/RANKL 系统介导的。 简介胰岛素样生长因子 I (IGF-I) 是耦合骨重塑、激活形成和吸收的重要因素。与许多关于IGF-I在骨形成中的作用的研究相比，关于其对骨吸收的影响的信息是有限的并且是相互矛盾的。成骨细胞产生的两种肽、骨保护素 (OPG) 和核因子-κB 配体受体激活剂 (RANKL) 的平衡对于骨吸收过程至关重要。本研究旨在分析中国健康女性血清IGF-I浓度与OPG、RANKL、OPG/RANKL比值以及BMD的关系。方法采用DXA测量504例绝经前和绝经后女性腰椎和股骨近端BMD。还测量了 IGF-I、OPG 和 RANKL 的血清水平。酌情采用Pearson相关和偏相关分析、方差分析、协方差分析和逐步多元回归分析。结果年龄与血清IGF-I水平呈负相关(r = −0.702,p< 0.001)。 IGF-I与OPG和OPG/RANKL比值呈负相关，与RANKL呈正相关。 IGF-I 和 BMD 之间的关系在调整年龄后消失。在绝经后女性中，骨质疏松女性的 IGF-I 低于 BMD 正常女性 (p= 0.056)，但 OPG、RANKL 和 OPG/RANKL 比值之间没有差异。 IGF-I最高五分位数的血清OPG水平显着低于IGF-I最低五分位数的血清OPG水平，而RANKL无差异。在多元回归分析模型中，血清IGF-I水平是中国女性骨量的主要决定因素。 结论综上所述，健康中国女性IGF-I下降与BMD之间的关系受年龄影响，而IGF-I对骨重塑（骨吸收）的影响可能是由OPG/RANKL系统介导的。
SummarySerum IGF-I level was negatively correlated with OPG and OPG/RANKL ratio, but positively correlated with RANKL. Serum OPG level in the highest quintile of IGF-I was significantly lower than that in the lowest. We conclude that the effect of IGF-I on bone remodeling may be mediated by the OPG/RANKL system.IntroductionInsulin-like growth factor I (IGF-I) is an important factor in coupling bone remodeling, activating both formation and resorption. Compared with the many studies on the role of IGF-I in bone formation, the information regarding its effects on bone resorption is limited and conflicting. The balance of the two peptides produced by osteoblasts, osteoprotegerin (OPG) and receptor activator of nuclear factor-κB ligand (RANKL), is critical for the bone resorption process. Our study was designed to analyze the relationships of serum concentrations of IGF-I with OPG, RANKL, OPG/RANKL ratio as well as BMDs in healthy Chinese women.MethodsBMDs at lumbar spine and proximal femur in 504 pre- and postmenopausal women were measured by DXA. Serum levels of IGF-I, OPG and RANKL were also measured. Pearson’s correlation and partial correlation analysis, ANOVA, covariance analysis and stepwise multiple regression analysis were used as appropriate.ResultsAge was negatively correlated with serum levels of IGF-I (r = −0.702,p< 0.001). IGF-I was negatively correlated with OPG and OPG/RANKL ratio, but positively correlated with RANKL. The relationship between IGF-I and BMDs disappeared after adjustment for age. In postmenopausal women, IGF-I was lower in women with osteoporosis than in those with normal BMD (p= 0.056), but no differences were found among OPG, RANKL and OPG/RANKL ratio. Serum levels of OPG in the highest quintile of IGF-I were significantly lower than those in the lowest quintile of IGF-I, while no difference was found in RANKL. In the multiple regression analysis model, serum levels of IGF-I were the main determinants of the bone mass in Chinese women.ConclusionsIn conclusion, the relationship between decreasing IGF-I and BMDs in healthy Chinese women influenced by age, whereas the effect of IGF-I on bone remodeling (bone resorption) may be mediated by the OPG/RANKL system.
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影响因子：
4.1
作者：
T. Seck;A. Bretz;R. Krempien;B. Krempien;R. Ziegler;J. Pfeilschifter
通讯作者：
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DOI：
10.1210/jcem.86.4.7377
发表时间：
2001-04
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1210/jcem.86.7.7657
发表时间：
2001
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
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通讯作者：
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影响因子：
3.2
作者：
S. Yakar;C. Rosen
通讯作者：
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