Clinical Medicine Insights: Endocrinology and Diabetes O R I G I N a L R E S E a R C H Low Bone Mass Is Associated with Increased Carotid Intima Media Thickness in Men with Type 2 Diabetes Mellitus
Clinical Medicine Insights: Endocrinology and Diabetes O R I G I N a L R E S E a R C H Low Bone Mass Is Associated with Increased Carotid Intima Media Thickness in Men with Type 2 Diabetes Mellitus
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临床医学见解：内分泌学和糖尿病 O R I G I N a L R E S E a R C H 低骨量与 2 型糖尿病男性颈动脉内膜中层厚度增加相关
DOI：
10.1210/jcem.86.7.7657
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
F. Bandeira
中科院分区：
文献类型：
--
作者：
Mario De;Almeida Pereira Coutinho;E. Bandeira;Juliana Maria Coelho;Maia De Almeida;Emanuelle Tenorio;Albuquerque Madruga Godoi;G. Vasconcelos;F. Bandeira
开放获取 本文及数千篇其他论文的完全开放获取：摘要：骨质疏松症和动脉粥样硬化具有共同的危险因素，一些研究已证明低骨量与心血管发病率和死亡率增加之间的关联。然而，大多数研究都集中在女性身上，只有少数研究针对 2 型糖尿病 (T2DM) 患者。颈动脉内膜中层厚度（CIMT）的测量能够检测早期动脉粥样硬化变化，并且是心血管事件的预测标志。本研究的目的是评估 T2DM 男性的 CIMT 及其与骨矿物质密度 (BMD)（股骨颈 (FN) 和腰椎 (LS)）的关系。我们对 24 名 T2DM 男性（年龄 61 ± 6.4 岁）进行了一项横断面研究，并评估了代谢因素、骨密度测定值以及使用 B 型 Logic-E 超声机测量的 CIMT。 75%的患者自诊断T2DM起已超过5年，其中41.6%正在使用他汀类药物，平均体重指数（BMI）为28.1 ± 3.4 kg/m 2 ，腹围6 mg/dL。根据 BMD 将患者分层。 FN BMD 正常组的平均 CIMT 为 0.7 mm，骨量低（骨质减少或骨质疏松）组的 CIMT 为 0.86 mm（P = 0.007）。此外，我们的数据表明，2 型糖尿病男性的 FN 处 BMD 与 CIMT 之间没有显着差异，这与动脉粥样硬化疾病的传统危险因素和糖尿病控制程度无关。
Open Access Full open access to this and thousands of other papers at Abstract: Osteoporosis and atherosclerosis share common risk factors and the association of low bone mass with increased cardio-vascular morbidity and mortality has been demonstrated in some studies. Nevertheless, most studies have been focused on women and only a few on individuals with type 2 diabetes mellitus (T2DM). The measurement of carotid intimal-medial thickness (CIMT) is able to detect early atherosclerotic changes and is a predictive marker of cardiovascular events. The aim of this study was to assess the CIMT and its relationship with bone mineral density (BMD) (in the femoral neck (FN) and lumbar spine (LS)) in men with T2DM. We conducted a cross-sectional study with 24 men with T2DM (aged 61 ± 6.4 years) and evaluated metabolic factors, bone densitom-etry values, and CIMT measured using B-mode Logic-E ultrasound machine. More than 5 years since the diagnosis of T2DM had passed in 75% of the patients, 41.6% were in statin use, mean body mass index (BMI) was 28.1 ± 3.4 kg/m 2 , abdominal circumference6 mg/dL. The patients were stratified into groups according to BMD. The group with normal BMD at FN had mean CIMT of 0.7 mm and the group with low bone mass (osteopenia or osteoporosis) had CIMT of 0.86 mm (P = 0.007). In addition, there were no significant differences between Our data demonstrate a negative association between BMD at the FN and CIMT in type 2 diabetic men, which was unrelated to the traditional risk factors for atherosclerotic disease and degree of diabetes control.
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影响因子：
5
作者：
L. Chambless;A. Folsom;L. Clegg;A. Sharrett;E. Shahar;F. Nieto;W. Rosamond;G. Evans
通讯作者：
L. Chambless;A. Folsom;L. Clegg;A. Sharrett;E. Shahar;F. Nieto;W. Rosamond;G. Evans
影响因子：
5
作者：
Chambless, LE;Heiss, G;Clegg, LX
通讯作者：
Clegg, LX
影响因子：
158.5
作者：
O'Leary, DH;Polak, JF;Wolfson, SK
通讯作者：
Wolfson, SK
影响因子：
5.8
作者：
Schwartz, Ann V.;Garnero, Patrick;Bauer, Douglas C.
通讯作者：
Bauer, Douglas C.