Evaluation of reward processes in an animal model of depression.
Evaluation of reward processes in an animal model of depression.
复制标题
抑郁症动物模型中奖励过程的评估。
DOI：
10.1007/s00213-006-0630-x
复制
发表时间：
2007
影响因子：
3.4
通讯作者：
Cryan,JohnF
中科院分区：
文献类型：
--
作者：
Slattery,DavidA;Markou,Athina;Cryan,JohnF
RationaleAnhedonia is a core symptom of major depression. Deficits in reward function, which underlie anhedonia, can be readily assessed in animals. Therefore, anhedonia may serve as an endophenotype for understanding the neural circuitry and molecular pathways underlying depression.ObjectiveSurprisingly, there is scant knowledge regarding alterations in brain reward function after olfactory bulbectomy (OB), an animal model which results in a behavioural syndrome responsive to chronic antidepressant treatment. Therefore, the present studies aimed to assess reward function after bulbectomy.Materials and methodsThe present study utilized sucrose preference, cocaine-induced hyperlocomotion and intra-cranial self-stimulation (ICSS) responding to examine reward processes in the OB model.ResultsBulbectomized animals showed a marked preference (>90%) for 0.8% sucrose solution compared with water; similar to the preference exhibited by sham controls. Importantly, there were pronounced deficits in brain reward function, as assessed using ICSS, which lasted 8 days before returning to baseline levels. Furthermore, bulbectomized animals were hyper-responsive to the locomotor stimulating properties of an acute and a repeated cocaine regimen. However, no difference in ICSS facilitation was observed in response to an acute cocaine injection.ConclusionsTaken together, these results suggest that bulbectomized rats display alterations in brain reward function, but these changes are not long-lasting and thus, not amenable to investigating the effects of pharmacological interventions. However, given that OB animals are hypersensitive to drugs of abuse, bulbectomy may be an appropriate inducing factor for the development of animal models of co-morbid depression and drug dependence.
登录
查看更多内容
乳头瘤病毒基因表达的细胞控制缺陷导致人类生殖器癌持续病毒感染的细胞内监测
DOI：
--
发表时间：
1986
期刊：
The Lancet
影响因子：
--
作者：
H. Hausen
通讯作者：
H. Hausen
生殖器尖锐湿疣和宫颈癌中人乳头瘤病毒 DNA 和信使 RNA 的原位杂交检测。
影响因子：
3.3
作者：
Stoler,MH;Broker,TR
通讯作者：
Broker,TR
影响因子：
4.7
作者：
A. Meisels;C. Morin
通讯作者：
C. Morin
鲍温样丘疹病：存在人乳头瘤病毒 (HPV) 结构抗原和 HPV 16 相关 DNA 序列
DOI：
--
发表时间：
1985
期刊：
影响因子：
--
作者：
G. Gross;M. Hagedorn;H. Ikenberg;T. Rufli;Catherine Dahlet;E. Grosshans;L. Gissmann
通讯作者：
L. Gissmann
生殖器疣的自然史。
DOI：
--
发表时间：
1971
期刊：
The British journal of venereal diseases
影响因子：
--
作者：
J. Oriel
通讯作者：
J. Oriel