Simple Dipyrrin Analogues of Prodigiosin for Use as Colistin Adjuvants.
Simple Dipyrrin Analogues of Prodigiosin for Use as Colistin Adjuvants.
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DOI：
10.1002/cmdc.202200286
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发表时间：
2022-08-17
期刊：
影响因子：
3.4
通讯作者：
Melander, Christian
中科院分区：
文献类型：
--
作者：
Siwawannapong, Kittipan;Nemeth, Ansley M.;Melander, Roberta J.;Rong, Jie;Davis, Jonathan R.;Taniguchi, Masahiko;Carpenter, Morgan E.;Lindsey, Jonathan S.;Melander, Christian
Multidrug resistant (MDR) bacteria are an increasing public health problem. One promising alternative to the development of new antibiotics is the use of antibiotic adjuvants, which would allow the continued use of FDA-approved antibiotics that have been rendered ineffective due to resistance. Here, we report a series of dipyrrins and pyrrole derivatives designed as analogues of prodigiosin and obatoclax, several of which potentiate the activity of colistin against Klebsiella pneumoniae, with lead compounds also potentiating colistin against Acinetobacter baumannii and Pseudomonas aeruginosa. A series of dipyrrins was identified that supresses colistin resistance in highly resistant strains of K. pneumoniae, A. baumannii and P. aeruginosa. The lead compound lowers the colistin MIC from 512 to ≤1 μg/mL at a concentration of 15 μM against K. pneumoniae B9.
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影响因子：
--
作者：
Santajit S;Indrawattana N
通讯作者：
Indrawattana N
DOI：
10.1016/j.btre.2021.e00604
发表时间：
2021-03
期刊：
Biotechnology reports (Amsterdam, Netherlands)
影响因子：
--
作者：
Yadav S;Kapley A
通讯作者：
Kapley A
影响因子：
5.3
作者：
Mattingly AE;Cox KE;Smith R;Melander RJ;Ernst RK;Melander C
通讯作者：
Melander C
DOI：
10.1073/pnas.0709443104
发表时间：
2007-12-04
影响因子：
11.1
作者：
Nguyen, Mai;Marcellus, Richard C.;Shore, Gordon C.
通讯作者：
Shore, Gordon C.
影响因子：
4.9
作者：
Sampson, Timothy R.;Liu, Xiang;Weiss, David S.
通讯作者：
Weiss, David S.