Characterization of Spinal Sensorimotor Network Using Transcutaneous Spinal Stimulation during Voluntary Movement Preparation and Performance.
Characterization of Spinal Sensorimotor Network Using Transcutaneous Spinal Stimulation during Voluntary Movement Preparation and Performance.
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DOI：
10.3390/jcm10245958
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发表时间：
2021-12-18
影响因子：
3.9
通讯作者：
Sayenko DG
中科院分区：
文献类型：
--
作者：
Steele AG;Atkinson DA;Varghese B;Oh J;Markley RL;Sayenko DG
经皮脊髓电刺激（TSS）可用于选择性地激活运动池的基础上，他们的解剖安排在腰骶扩大。这些脊髓运动激活的空间模式可能具有重要的临床意义，特别是当需要针对特定的肌肉群时。然而，我们对在自愿运动准备和表现期间投射到激动剂和拮抗剂肌肉的运动池之间的净效应和相互作用的理解仍然有限。本研究旨在系统地研究和区分腰骶神经网络棘上输入的多节段收敛，在神经功能完整的参与者进行自主腿部运动之前和期间。在实验中，参与者（N = 13）进行了等距(1)膝关节屈曲和(2)伸直，以及(3)跖屈和(4)背屈。在肌肉收缩期间，以及在听觉或触觉刺激后的50 ~ 250 ms内，在T12-L1椎体上传递一对脉冲，刺激间隔为50 ms，以表征运动准备期间净脊髓运动输出的时间分布。同侧激动剂和对侧拮抗剂诱发运动电位的促进作用早在提示后50 ms出现，并在运动开始前增强。这些结果表明，下行驱动以特定的、功能相关的时空模式调节了脊髓感觉运动网络中神经元间回路的活动，这对神经系统疾病患者神经网络状态的表征具有直接意义。
Transcutaneous electrical spinal stimulation (TSS) can be used to selectively activate motor pools based on their anatomical arrangements in the lumbosacral enlargement. These spatial patterns of spinal motor activation may have important clinical implications, especially when there is a need to target specific muscle groups. However, our understanding of the net effects and interplay between the motor pools projecting to agonist and antagonist muscles during the preparation and performance of voluntary movements is still limited. The present study was designed to systematically investigate and differentiate the multi-segmental convergence of supraspinal inputs on the lumbosacral neural network before and during the execution of voluntary leg movements in neurologically intact participants. During the experiments, participants (N = 13) performed isometric (1) knee flexion and (2) extension, as well as (3) plantarflexion and (4) dorsiflexion. TSS consisting of a pair pulse with 50 ms interstimulus interval was delivered over the T12-L1 vertebrae during the muscle contractions, as well as within 50 to 250 ms following the auditory or tactile stimuli, to characterize the temporal profiles of net spinal motor output during movement preparation. Facilitation of evoked motor potentials in the ipsilateral agonists and contralateral antagonists emerged as early as 50 ms following the cue and increased prior to movement onset. These results suggest that the descending drive modulates the activity of the inter-neuronal circuitry within spinal sensorimotor networks in specific, functionally relevant spatiotemporal patterns, which has a direct implication for the characterization of the state of those networks in individuals with neurological conditions.
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DOI：
10.1007/978-1-4939-6664-6_2
发表时间：
2016-01-01
期刊：
PHYSIOLOGY OF EXERCISE IN SPINAL CORD INJURY
影响因子：
--
作者：
Edgerton, V. Reggie;Roy, Roland R.
通讯作者：
Roy, Roland R.
DOI：
10.1016/0168-5597(93)90131-8
发表时间：
1993-06-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
CALANCIE, B;BROTON, JG;AYYAR, DR
通讯作者：
AYYAR, DR
影响因子：
5.5
作者：
ECCLES, JC;MAGNI, F;ECCLES, RM
通讯作者：
ECCLES, RM
影响因子：
--
作者：
Fong AJ;Roy RR;Ichiyama RM;Lavrov I;Courtine G;Gerasimenko Y;Tai YC;Burdick J;Edgerton VR
通讯作者：
Edgerton VR
DOI：
10.1177/1073858416683681
发表时间：
2017-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Gerasimenko Y;Sayenko D;Gad P;Liu CT;Tillakaratne NJK;Roy RR;Kozlovskaya I;Edgerton VR
通讯作者：
Edgerton VR