Intercellular Communication in the Islet of Langerhans in Health and Disease.
Intercellular Communication in the Islet of Langerhans in Health and Disease.
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DOI：
10.1002/cphy.c200026
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发表时间：
2021-06-30
影响因子：
5.8
通讯作者：
Piston DW
中科院分区：
文献类型：
--
作者：
Ng XW;Chung YH;Piston DW
血糖的稳定需要胰岛的正常功能，胰岛分别从β-，α-和δ-细胞分泌胰岛素、胰高血糖素和生长抑素。每种类型的胰岛细胞都有葡萄糖感应和分泌作用的内在机制，但这些内在机制本身不能解释观察到的完整胰岛的分泌特征。分泌的调节涉及胰岛细胞类型之间的相互联系的机制。与完整的胰岛和体内的胰岛相比，胰岛细胞在扩散时失去了正常的功能特征和分泌行为。在分散的胰岛细胞中，胰岛素分泌的葡萄糖反应与整个胰岛相比减弱，膜电位和细胞内钙活性的协调振荡以及两相胰岛素分泌谱缺失，胰升糖素分泌表现出更高的基础分泌谱和与完整胰岛相反的葡萄糖依赖反应。这些观察结果突出了胰岛内细胞间通讯的关键作用，以及这些通讯途径对正常的激素和非激素分泌以及葡萄糖稳态是如何至关重要的。此外，由细胞间胰岛通讯缺陷引起的胰岛分泌产物分泌失调与糖尿病有关。胰岛环境中的细胞间通信包括多种机制，包括缝隙连接耦合的电突触，相邻细胞之间的旁分泌相互作用，以及以旁分泌信号形式的细胞间直接接触。在这篇综述中，我们描述了有助于每种胰岛细胞类型正确的胰岛功能的各种机制，以及相同和不同的胰岛细胞类型之间的细胞间通讯是如何协调的。
Blood glucose homeostasis requires proper function of pancreatic islets, which secrete insulin, glucagon and somatostatin from the β-, α- and δ-cells respectively. Each islet cell type is equipped with intrinsic mechanisms for glucose sensing and secretory actions, but these intrinsic mechanisms alone cannot explain the observed secretory profiles from intact islets. Regulation of secretion involves interconnected mechanisms among and between islet cell types. Islet cells lose their normal functional signatures and secretory behaviors upon dispersal as compared to intact islets and in vivo. In dispersed islet cells, the glucose response of insulin secretion is attenuated from that seen from whole islets, coordinated oscillations in membrane potential and intracellular Ca2+ activity, as well as the two-phase insulin secretion profile are missing, and glucagon secretion displays higher basal secretion profile and a reverse glucose-dependent response from that of intact islets. These observations highlight the critical roles of intercellular communication within the pancreatic islet, and how these communication pathways are crucial for proper hormonal and non-hormonal secretion and glucose homeostasis. Further, misregulated secretions of islet secretory products that arise from defective intercellular islet communication are implicated in diabetes. Intercellular communication within the islet environment comprises multiple mechanisms, including electrical synapses from gap junctional coupling, paracrine interactions among neighboring cells, and direct cell-to-cell contacts in the form of juxtacrine signaling. In this review, we describe the various mechanisms that contribute to proper islet function for each islet cell type and how intercellular islet communications are coordinated among the same and different islet cell types.
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影响因子：
10.9
作者：
Benninger, Richard K. P.;Piston, David W.
通讯作者：
Piston, David W.
影响因子：
7.7
作者：
Ainscow, EK;Rutter, GA
通讯作者：
Rutter, GA
影响因子：
9.8
作者：
BENOIT, R;ESCH, F;MUFSON, EJ
通讯作者：
MUFSON, EJ
影响因子：
16.6
作者：
Arrojo e Drigo, Rafael;Jacob, Stefan;Berggren, Per-Olof
通讯作者：
Berggren, Per-Olof
影响因子：
5.8
作者：
Batterham, RL;Le Roux, CW;Bloom, SR
通讯作者：
Bloom, SR