Transformation of Our Understanding of Breathing Control by Molecular Tools.
Transformation of Our Understanding of Breathing Control by Molecular Tools.
复制标题
DOI：
10.1146/annurev-physiol-021522-094142
复制
发表时间：
2023-02-10
影响因子：
18.2
通讯作者：
中科院分区：
文献类型：
--
作者：
呼吸的节律性对正常的生理至关重要。即便如此，呼吸的多功能性还是很丰富的。外部信号不断地改变呼吸，在水下停止呼吸，或在用力时加深呼吸。内在暗示利用呼吸来表达情绪，如沮丧的叹息和无聊的哈欠。呼吸与使用我们的嘴和喉咙的其他动作相协调，包括说话、咀嚼和吞咽。此外，我们对呼吸强度的感知可以决定我们的感受，例如在平静冥想和引发焦虑的过度换气的缓慢呼吸期间。心跳来自心脏的外周起搏器，但呼吸的自动化来自脑干内的神经丛，使之能够与其他大脑区域相互作用，从而实现多功能。在这里，我们记录了最近细胞和分子工具的转变如何有助于我们欣赏呼吸控制电路中神经元类型的多样性，以及它们如何赋予呼吸的多功能。
The rhythmicity of breath is vital for normal physiology. Even so, breathing is enriched with multifunctionality. External signals constantly change breathing, stopping it when under water or deepening it during exertion. Internal cues utilize breath to express emotions such as sighs of frustration and yawns of boredom. Breathing harmonizes with other actions that use our mouth and throat, including speech, chewing, and swallowing. In addition, our perception of breathing intensity can dictate how we feel, such as during the slow breathing of calming meditation and anxiety-inducing hyperventilation. Heartbeat originates from a peripheral pacemaker in the heart, but the automation of breathing arises from neural clusters within the brain-stem, enabling interaction with other brain areas and thus multifunctionality. Here, we document how the recent transformation of cellular and molecular tools has contributed to our appreciation of the diversity of neuronal types in the breathing control circuit and how they confer the multifunctionality of breathing.
登录
查看更多内容
影响因子：
5.5
作者：
BONHAM, AC;JOAD, JP
通讯作者：
JOAD, JP
影响因子：
2.5
作者：
COHEN, MI;FELDMAN, JL
通讯作者：
FELDMAN, JL
影响因子：
64.5
作者：
Chang RB;Strochlic DE;Williams EK;Umans BD;Liberles SD
通讯作者：
Liberles SD
DOI：
10.1073/pnas.1110416108
发表时间：
2011-12-13
影响因子：
11.1
作者：
D'Autreaux, Fabien;Coppola, Eva;Brunet, Jean-Francois
通讯作者：
Brunet, Jean-Francois
影响因子：
25
作者：
Blanchi, B;Kelly, LM;Sieweke, MH
通讯作者：
Sieweke, MH