Singlet-assisted diffusion-NMR (SAD-NMR): extending the scope of diffusion tensor imaging via singlet NMR.

Singlet-assisted diffusion-NMR (SAD-NMR): extending the scope of diffusion tensor imaging via singlet NMR.
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DOI:
10.3389/fchem.2023.1224336
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发表时间:
2023
影响因子:
5.5
通讯作者:
--
中科院分区:
化学3区
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--
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在这项研究中,长寿命核单重态有序方法与扩散张量成像相结合,目的是表征分子在高达一毫米大小的大孔隙中自由扩散的完整扩散张量。由于纵向磁化的弛豫衰减常数的限制,这种尺寸在传统的扩散张量成像中是无法达到的。本文讨论了一种单线辅助扩散张量成像方法,该方法能够规避这种限制,并通过对直径为1毫米的圆柱形通道的塑料幻影的模拟和实验证明了它提供的新的可能性。
In this study, long-lived nuclear singlet order methods are combined with diffusion tensor imaging with the purpose of characterizing the full diffusion tensor of molecules diffusing freely in large pores of up to a millimeter in size. Such sizes are out of reach in conventional diffusion tensor imaging because of the limitations imposed by the relaxation decay constant of the longitudinal magnetization. A singlet-assisted diffusion tensor imaging methodology able to circumvent such limitations is discussed, and the new possibilities that it offers are demonstrated through simulation and experiments on plastic phantoms containing cylindrical channels of 1 mm in diameter.
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