The Structural Dynamics, Complexity of Interactions, and Functions in Cancer of Multi-SAM Containing Proteins.
The Structural Dynamics, Complexity of Interactions, and Functions in Cancer of Multi-SAM Containing Proteins.
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结构动力学，相互作用的复杂性，以及含有多SAM的蛋白质在癌症中的功能。
作者：
癌症是全世界死亡的主要原因，其中大多数死亡是肿瘤转移（癌细胞从原发部位扩散）的结果。无菌α基序（SAM）结构域是一个重要的蛋白质模块，可以调节蛋白质之间的许多相互作用，包括那些对癌症发展或转移重要的蛋白质。本文综述了一组研究不足的蛋白质，含有多个SAM域的文献。我们的重点将放在这些蛋白质，特别强调有关其SAM结构域内存在的结构动力学和相互作用安排的最新发现。我们还将讨论它们的作用、功能和规则的相似性和独特性。我们的目标是提供这些SAM结构域和这些蛋白质的更好的理解，这可能会提供线索，开发新的抗癌药物。SAM结构域是多种相互作用的关键介质，包括对于癌症的肿瘤发生或转移重要的那些，因此SAM结构域可以是开发癌症疗法的有吸引力的靶标。本文旨在探讨文献，特别是对最近的研究结果的结构动力学，调节和功能的SAM结构域的蛋白质含有一个以上的SAM（多SAM含有蛋白质，MSCPs）。这里的主题包括如何内在的障碍，一些SAM和一个额外的SAM结构域MSCPs增加其相互作用和寡聚化安排的复杂性。这些MSCPs之间存在许多相似之处，包括它们对癌细胞粘附、迁移和转移的影响。此外，它们都参与某些类型的受体介导的信号传导和神经学相关的功能或疾病，尽管具体的受体和功能各不相同。这篇综述还提供了一个简单的概述，研究蛋白质结构域的方法，这可能有助于非结构生物学家接触和建立新的合作，研究他们最喜欢的蛋白质结构域/区域。总体而言，本次审查的目的是提供各种情况下，可能会提供线索，以更好地了解SAM域和MSCPs在癌症中的作用的代表性例子一般。
Cancer is a leading cause of death worldwide, with most of these deaths being the result of tumor metastasis (spread of cancer cells from the primary site). The sterile alpha motif (SAM) domain is a crucial protein module that can regulate many interactions among proteins, including those important for cancer development or metastasis. This review explores the literature on a group of under-studied proteins that contain multiple SAM domains. Our focus will be on these proteins, with a particular emphasis on the latest findings regarding the structural dynamics and interaction arrangements present within their SAM domains. We will also discuss the similarities as well as the uniqueness of their effects, functions, and regulations. We aim to provide a better understanding of these SAM domains and these proteins, which may offer clues to develop novel anticancer drugs. SAM domains are crucial mediators of diverse interactions, including those important for tumorigenesis or metastasis of cancers, and thus SAM domains can be attractive targets for developing cancer therapies. This review aims to explore the literature, especially on the recent findings of the structural dynamics, regulation, and functions of SAM domains in proteins containing more than one SAM (multi-SAM containing proteins, MSCPs). The topics here include how intrinsic disorder of some SAMs and an additional SAM domain in MSCPs increase the complexity of their interactions and oligomerization arrangements. Many similarities exist among these MSCPs, including their effects on cancer cell adhesion, migration, and metastasis. In addition, they are all involved in some types of receptor-mediated signaling and neurology-related functions or diseases, although the specific receptors and functions vary. This review also provides a simple outline of methods for studying protein domains, which may help non-structural biologists to reach out and build new collaborations to study their favorite protein domains/regions. Overall, this review aims to provide representative examples of various scenarios that may provide clues to better understand the roles of SAM domains and MSCPs in cancer in general.
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影响因子：
3.7
作者：
Tong J;Sydorskyy Y;St-Germain JR;Taylor P;Tsao MS;Moran MF
通讯作者：
Moran MF
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5.7
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Stafford, Ryan L.;Hinde, Elizabeth;Knight, Mary Jane;Pennella, Mario A.;Ear, Jason;Digman, Michelle A.;Gratton, Enrico;Bowie, James U.
通讯作者：
Bowie, James U.
影响因子：
5.6
作者：
Henen MA;Myers W;Schmitt LR;Wade KJ;Born A;Nichols PJ;Vögeli B
通讯作者：
Vögeli B
影响因子：
3.7
作者：
Stubblefield K;Chean J;Nguyen T;Chen CJ;Shively JE
通讯作者：
Shively JE
影响因子：
3.2
作者：
Mercurio, Flavia A.;Marasco, Daniela;Pirone, Luciano;Scognamiglio, Pasqualina L.;Pedone, Emilia M.;Pellecchia, Maurizio;Leone, Marilisa
通讯作者：
Leone, Marilisa