Success rates and immunologic responses of autogenic, allogenic, and xenogenic treatments to repair articular cartilage defects.
Success rates and immunologic responses of autogenic, allogenic, and xenogenic treatments to repair articular cartilage defects.
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DOI：
10.1089/ten.teb.2008.0189
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Athanasiou KA
中科院分区：
文献类型：
--
作者：
Revell CM;Athanasiou KA
本文综述了目前关节软骨修复的方法，不仅在其再生潜力方面，而且作为一个功能的免疫反应。由于缺乏免疫原性反应，自体修复技术，包括骨软骨栓移植、软骨细胞植入和微骨折，是最广泛接受的临床治疗选择，但仅报告了中等的移植成功率。尽管悬浮的同种异体软骨细胞显示在植入后引起免疫应答，但使用同种异体软骨细胞的同种异体骨软骨栓和组织工程化移植物表现出可耐受的免疫原性应答。此外，这些修复技术产生的新组织的成功率接近目前可用的自体修复技术，同时消除了供体组织稀缺的主要障碍。迄今为止，有限的研究已经进行了异种组织，虽然一些研究表明其长期成功的潜力。本文重点介绍软骨修复的各种治疗方案及其相关的成功率和免疫反应。
This review examines current approaches available for articular cartilage repair, not only in terms of their regeneration potential, but also as a function of immunologic response. Autogenic repair techniques, including osteochondral plug transplantation, chondrocyte implantation, and microfracture, are the most widely accepted clinical treatment options due to the lack of immunogenic reactions, but only moderate graft success rates have been reported. Although suspended allogenic chondrocytes are shown to evoke an immune response upon implantation, allogenic osteochondral plugs and tissue-engineered grafts using allogenic chondrocytes exhibit a tolerable immunogenic response. Additionally, these repair techniques produce neotissue with success rates approaching those of currently available autogenic repair techniques, while simultaneously obviating their major hindrance of donor tissue scarcity. To date, limited research has been performed with xenogenic tissue, although several studies demonstrate the potential for its long-term success. This article focuses on the various treatment options for cartilage repair and their associated success rates and immunologic responses.
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DOI：
10.1302/0301-620x.85b2.13543
发表时间：
2003-03-01
影响因子：
--
作者：
Bentley, G;Biant, LC;Pringle, J
通讯作者：
Pringle, J
影响因子：
--
作者：
DAYER, E;MATHAI, L;POOLE, AR
通讯作者：
POOLE, AR
影响因子：
1.9
作者：
Behrens, Peter;Bitter, Thomas;Russlies, Martin
通讯作者：
Russlies, Martin
DOI：
10.1302/0301-620x.74b1.1732235
发表时间：
1992-01-01
影响因子：
--
作者：
BEAVER, RJ;MAHOMED, M;GROSS, AE
通讯作者：
GROSS, AE
DOI：
10.1159/000231262
发表时间：
1974-01-01
期刊：
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY
影响因子：
--
作者：
ELVES, MW
通讯作者：
ELVES, MW