Improvement of dispersion stability and characterization of upconversion nanophosphors covalently modified with PEG as a fluorescence bioimaging probe.
Improvement of dispersion stability and characterization of upconversion nanophosphors covalently modified with PEG as a fluorescence bioimaging probe.
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DOI：
10.1007/s10853-008-2776-x
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发表时间：
2008
影响因子：
4.5
通讯作者：
Maeda, Mizuo
中科院分区：
文献类型：
--
作者：
Zako, Tamotsu;Nagata, Hiroyasu;Terada, Naofumi;Sakono, Masafumi;Soga, Kohei;Maeda, Mizuo
上转换（UC）磷光体（UCP）是掺杂有稀土离子的陶瓷材料。这些材料可以吸收和上转换红外（IR）辐射发射可见光的逐步激发之间的离散能级的稀土离子。UCP是用于生物成像的潜在有用的试剂，因为使用低能光子避免了光毒性。使用UCP纳米粒子作为生物成像探针需要表面改性，以努力提高在水环境中的分散稳定性。在这项研究中，我们共价连接聚（乙二醇）（PEG）的Er掺杂的Y2 O3纳米粒子的表面，并首次证明，PEG共价结合到Y2 O3表面显着提高在水中的分散稳定性。成功地观察到PEG修饰的Er-Y2 O3纳米粒子在红外光激发下的UC发射。我们还表明，PEG修饰的Er-Y2 O3纳米粒子没有表现出细胞毒性。这些观察结果为PEG修饰的UCP纳米颗粒作为生物成像工具的潜在用途提供了强有力的支持。
Upconverting (UC) phosphors (UCPs) are ceramic materials doped with rare earth ions. These materials can absorb and upconvert infrared (IR) radiation to emit visible light by the stepwise excitation among discrete energy levels of the rare earth ions. UCPs are potentially useful reagents for use in bioimaging since the use of low energy photons avoids photo-toxicity. The use of UCP nanoparticles as bioimaging probes requires surface modifications in an effort to improve dispersion stability in aqueous milieu. In this study, we covalently attached poly(ethylene glycol) (PEG) to the surface of Er-doped Y2O3 nanoparticles and firstly demonstrated that PEG covalently bound to the Y2O3 surface markedly improved dispersion stability in water. UC emission of PEG-modified Er–Y2O3 nanoparticles excited with IR light was successfully observed. We also showed that PEG-modified Er–Y2O3 nanoparticles exhibit no cell-toxicity. These observations lend strong support to the potential use of PEG-modified UCP nanoparticles as bioimaging tools.
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影响因子：
2.9
作者：
Zijlmans, HJMAA;Bonnet, J;Tanke, HJ
通讯作者：
Tanke, HJ
影响因子：
46.9
作者：
Jaiswal, JK;Mattoussi, H;Simon, SM
通讯作者：
Simon, SM
影响因子：
11.2
作者：
Chen, XY;Conti, PS;Moats, RA
通讯作者：
Moats, RA
影响因子：
4.3
作者：
Sivakumar, Sri;Diamente, Peter R.;van Veggel, Frank C. J. M.
通讯作者：
van Veggel, Frank C. J. M.
DOI：
10.2494/photopolymer.19.145
发表时间：
2006-01-01
影响因子：
0.8
作者：
Konishi, Tomoya;Yamada, Masayoshi;Nagasaki, Yukio
通讯作者：
Nagasaki, Yukio