Point-prevalence survey of outpatient antibiotic prescription at a tertiary medical center in Sri Lanka: opportunities to improve prescribing practices for respiratory illnesses.
Point-prevalence survey of outpatient antibiotic prescription at a tertiary medical center in Sri Lanka: opportunities to improve prescribing practices for respiratory illnesses.
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DOI：
10.1186/s12879-021-05804-6
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发表时间：
2021-01-21
影响因子：
3.7
通讯作者：
Tillekeratne LG
中科院分区：
文献类型：
--
作者：
Zhang HL;Bodinayake C;Wijayaratne GB;Jayatissa P;Piyasiri DLB;Kurukulasooriya R;Sheng T;Nagahawatte A;Woods C;Tillekeratne LG
抗生素使用不当与抗生素耐药性在全球范围内的传播有关，但有关中低收入国家抗生素使用的系统数据有限。本研究的目的是评估在斯里兰卡的门诊护理环境中抗生素处方的患病率和模式。这项横断面调查于2019年2月至4月在斯里兰卡南部省的一家公立三级医疗中心的门诊部进行。在连续的门诊病人提出的照顾，问卷口头管理的系统随机样本，以捕捉有关患者的人口统计学，疾病特征和访问结果的信息。处方数据来自门诊药房的电子处方系统。在409名接受调查的患者中，146名（35.7%）被开了抗生素。最常使用的药物是阿莫西林（41例患者，占抗生素使用者的28.1%）和第一代头孢菌素（38例，占26.0%）。呼吸道适应症是抗生素使用的最常见原因，占所有抗生素处方的69（47.3%）。66.1%的咳嗽患者和78.8%的流涕或鼻塞患者使用抗生素。在所有抗生素接受者中，6例（4.1%）接受了诊断研究。据观察，抗生素处方的使用率很高，特别是用于治疗呼吸系统疾病。这些数据支持在斯里兰卡门诊环境中需要改善抗菌药物管理。在线版本包含补充材料，可通过10.1186/s12879-021-05804-6获得。
Inappropriate antibiotic use is linked to the spread of antimicrobial resistance worldwide, but there are limited systemic data on antibiotic utilization in low- and middle-income countries. The purpose of this study was to evaluate the prevalence and patterns of antibiotic prescription in an ambulatory care setting in Sri Lanka. This cross-sectional survey was conducted at the Outpatient Department of a public tertiary medical center in Southern Province, Sri Lanka from February to April 2019. Among consecutive outpatients presenting for care, questionnaires were verbally administered to a systematic random sample to capture information about patient demographics, illness characteristics, and visit outcomes. Prescription data were obtained from the outpatient pharmacy’s electronic prescribing system. Of 409 surveyed patients, 146 (35.7%) were prescribed an antibiotic. The most frequently prescribed agents were amoxicillin (41 patients, 28.1% of antibiotic recipients) and first-generation cephalosporins (38, 26.0%). Respiratory indications were the most common reason for antibiotic use, comprising 69 (47.3%) of all antibiotic prescriptions. Antibiotics were prescribed for 66.1% of patients presenting with cough and 78.8% of those presenting with rhinorrhea or nasal congestion. Among all antibiotic recipients, 6 (4.1%) underwent diagnostic studies. A high prevalence of antibiotic prescription was observed, in particular for treatment of respiratory conditions. These data support the need for improved antimicrobial stewardship in the Sri Lankan outpatient setting. The online version contains supplementary material available at 10.1186/s12879-021-05804-6.
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影响因子：
2.9
作者：
Tillekeratne LG;Bodinayake CK;Dabrera T;Nagahawatte A;Arachchi WK;Sooriyaarachchi A;Stewart K;Watt M;Østbye T;Woods CW
通讯作者：
Woods CW
影响因子：
5.7
作者：
Hassali, Mohamed Azmi;Kamil, Tengku Karmila Tengku;Godman, Brian
通讯作者：
Godman, Brian
影响因子：
120.7
作者：
Fleming-Dutra, Katherine E.;Hersh, Adam L.;Hicks, Lauri A.
通讯作者：
Hicks, Lauri A.
影响因子：
56.3
作者：
Laxminarayan, Ramanan;Duse, Adriano;Cars, Otto
通讯作者：
Cars, Otto
老挝人民民主共和国的抗生素处方行为：一项知识，态度和实践调查。
影响因子：
11.1
作者：
Quet F;Vlieghe E;Leyer C;Buisson Y;Newton PN;Naphayvong P;Keoluangkhot V;Chomarat M;Longuet C;Steenkeste N;Jacobs J
通讯作者：
Jacobs J