Determinants of Urogenital Schistosomiasis Among Pregnant Women and its Association With Pregnancy Outcomes, Neonatal Deaths, and Child Growth.
Determinants of Urogenital Schistosomiasis Among Pregnant Women and its Association With Pregnancy Outcomes, Neonatal Deaths, and Child Growth.
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DOI：
10.1093/infdis/jiz664
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发表时间：
2021-04-23
期刊：
影响因子：
--
通讯作者：
Bourke CD
中科院分区：
文献类型：
--
作者：
Murenjekwa W;Makasi R;Ntozini R;Chasekwa B;Mutasa K;Moulton LH;Tielsch JM;Humphrey JH;Smith LE;Prendergast AJ;Bourke CD
血吸虫是一种引起泌尿生殖系统病理的寄生蠕虫。妊娠期泌尿生殖系统血吸虫病对出生结局和儿童生长的影响知之甚少。在津巴布韦农村进行的一项基于社区的整群随机试验中，4437名孕妇登记了泌尿生殖系统血吸虫病的危险因素。通过尿液镜检(≥-1、血吸虫卵)和尿液分析(血尿)确定感染情况。感染和妊娠结局之间的关系在病例对照分析中用条件Logistic回归进行了评估。使用广义估计方程评估1个月和18个月出生时母亲感染与出生体重和身长Z分数(LAZ)的关系。26.8%的孕妇检出尿路血吸虫病(虫卵阳性和/或血尿阳性)。与感染显著相关的危险因素有产妇年龄、教育程度、婚姻状况和宗教信仰、家庭饮用水源和厕所、研究地区和季节。泌尿生殖系统血吸虫病与不良妊娠结局(流产、死产、早产和小于胎龄)、出生体重、新生儿死亡或LAZ没有显著相关性。将孕妇纳入抗寄生虫治疗计划将使津巴布韦农村的大量妇女受益。然而，清除在这种情况下占主导地位的低强度感染不太可能对妊娠结局或儿童生长产生额外的好处。NCT01824940。泌尿生殖系统血吸虫病在津巴布韦农村孕妇中很常见(本研究中为n = 4437)，但感染与不良妊娠结局、新生儿死亡、出生体重或1或18个月大儿童的Z评分无关。
Schistosoma haematobium is a parasitic helminth that causes urogenital pathology. The impact of urogenital schistosomiasis during pregnancy on birth outcomes and child growth is poorly understood. Risk factors for urogenital schistosomiasis were characterized among 4437 pregnant women enrolled in a cluster-randomized community-based trial in rural Zimbabwe. Infection was defined via urine microscopy (≥1 S. haematobium egg) and urinalysis (hematuria). Associations between infection and pregnancy outcomes were assessed in case-control analyses using conditional logistic regression. The association of maternal infection with birthweight and length-for-age Z scores (LAZ) at 1 and 18 months of age were assessed using generalized estimating equations. Urogenital schistosomiasis (egg positive and/or hematuria positive) was detected in 26.8% of pregnant women. Risk factors significantly associated with infection were maternal age, education, marital status, and religion; household drinking water source and latrine; study region; and season. Urogenital schistosomiasis was not significantly associated with adverse pregnancy outcomes (miscarriage, stillbirth, preterm, and small-for-gestational age), birthweight, neonatal death, or LAZ. Including pregnant women in antihelminthic treatment programs would benefit a large number of women in rural Zimbabwe. However, clearance of the low-intensity infections that predominate in this context is unlikely to have additive benefits for pregnancy outcomes or child growth. NCT01824940. Urogenital schistosomiasis is common among pregnant women in rural Zimbabwe (n = 4437 in this study), but infection was not associated with adverse pregnancy outcomes, neonatal deaths, birthweight, or child length-for-age Z scores at 1 or 18 months of age.
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影响因子：
3.7
作者：
Galappaththi-Arachchige HN;Holmen S;Koukounari A;Kleppa E;Pillay P;Sebitloane M;Ndhlovu P;van Lieshout L;Vennervald BJ;Gundersen SG;Taylor M;Kjetland EF
通讯作者：
Kjetland EF
DOI：
10.4269/ajtmh.2011.10-0585
发表时间：
2011-03-01
影响因子：
3.3
作者：
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通讯作者：
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影响因子：
81.5
作者：
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影响因子：
3.8
作者：
Hegertun, Ingrid Elise Amlie;Gundersen, Kristin Marie Sulheim;Kjetland, Eyrun Floerecke
通讯作者：
Kjetland, Eyrun Floerecke
DOI：
10.1016/j.trstmh.2005.09.010
发表时间：
2006-08-01
影响因子：
2.2
作者：
Kjetland, Eyrun F.;Mduluza, Takafira;Gundersen, Svein Gunnar
通讯作者：
Gundersen, Svein Gunnar