M cells in antigen sampling in mucosal tissues.
M cells in antigen sampling in mucosal tissues.
复制标题
粘膜组织中抗原采样中的 M 细胞。
DOI:
10.1007/978-3-642-59951-4_2
复制
发表时间:
1999
影响因子:
--
通讯作者:
Neutra,MR
中科院分区:
文献类型:
--
作者:
Neutra,MR
The mucosal surfaces of the gastrointestinal and respiratory tracts are lined by epithelial barriers composed of cells joined by tight junctions. These gasket-like junctional structures are generally effective in excluding peptides and macromolecules with antigenic potential (Madaraet al. 1990). Mucosal surfaces are also provided with other defenses such as local secretions containing mucins and secretory immunoglobulin A (IgA) antibodies that tend to prevent antigens and pathogens from contacting the epithelium (Neutraet al. 1994). Nevertheless, to obtain samples from the external environment across this barrier, the mucosal immune system depends on a close collaboration between epithelial cells and antigen-presenting and lymphoid cells. These “lympho-epithelial complexes” allow transport of antigen samples across the mucosal barrier without compromising the integrity and protective functions of the epithelium.
登录
查看更多内容
影响因子:
6
作者:
Tor C. Savidge;M. Smith;P. James;P. Aldred
通讯作者:
P. Aldred
影响因子:
6
作者:
M. Smith;P. James;D. Tivey
通讯作者:
D. Tivey
影响因子:
16
作者:
M. Neutra;J. Kraehenbuhl
通讯作者:
J. Kraehenbuhl
DOI:
10.1164/ajrccm/138.6_pt_2.s10
发表时间:
1988
期刊:
The American review of respiratory disease
影响因子:
--
作者:
Neutra,MR;Wilson,JM;Weltzin,RA;Kraehenbuhl,JP
通讯作者:
Kraehenbuhl,JP
影响因子:
3.4
作者:
McDaniel,RV;Sharp,K;Brooks,D;McLaughlin,AC;Winiski,AP;Cafiso,D;McLaughlin,S
通讯作者:
McLaughlin,S