M cells in antigen sampling in mucosal tissues.

M cells in antigen sampling in mucosal tissues.
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粘膜组织中抗原采样中的 M 细胞。

DOI:
10.1007/978-3-642-59951-4_2
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发表时间:
1999
影响因子:
--
通讯作者:
Neutra,MR
Neutra,MR
中科院分区:
医学3区
文献类型:
--
作者:
Neutra,MR

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胃肠道和呼吸道的粘膜表面布满了由紧密连接连接的细胞组成的上皮屏障。这些垫圈样连接结构通常可有效排除具有抗原潜力的肽和大分子(Madaraet al. 1990)。粘液表面还提供有其他防御,例如含有粘蛋白和分泌性免疫球蛋白A(伊加)抗体的局部分泌物,其倾向于防止抗原和病原体接触上皮(Neutraet al.1994)。然而,为了从外部环境中获得穿过该屏障的样品,粘膜免疫系统依赖于上皮细胞与抗原呈递细胞和淋巴细胞之间的密切协作。这些“淋巴-上皮复合物”允许抗原样品运输穿过粘膜屏障,而不损害上皮的完整性和保护功能。
The mucosal surfaces of the gastrointestinal and respiratory tracts are lined by epithelial barriers composed of cells joined by tight junctions. These gasket-like junctional structures are generally effective in excluding peptides and macromolecules with antigenic potential (Madaraet al. 1990). Mucosal surfaces are also provided with other defenses such as local secretions containing mucins and secretory immunoglobulin A (IgA) antibodies that tend to prevent antigens and pathogens from contacting the epithelium (Neutraet al. 1994). Nevertheless, to obtain samples from the external environment across this barrier, the mucosal immune system depends on a close collaboration between epithelial cells and antigen-presenting and lymphoid cells. These “lympho-epithelial complexes” allow transport of antigen samples across the mucosal barrier without compromising the integrity and protective functions of the epithelium.
沙门氏菌诱导无菌小鼠派尔氏斑组织中 M 细胞的形成。
DOI: --
发表时间: 1991
影响因子: 6
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