Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair.

Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair.
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细胞核的功能结构:组织基因表达、复制和修复的调节机制。

DOI:
10.1016/j.tcb.2003.09.009
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发表时间:
2003
影响因子:
19
通讯作者:
Javed,Amjad
Javed,Amjad
中科院分区:
生物学1区
文献类型:
--
作者:
Stein,GaryS;Zaidi,SayyedK;Braastad,CoreyD;Montecino,Martin;vanWijnen,AndreJ;Choi,Je-Yong;Stein,JanetL;Lian,JaneB;Javed,Amjad

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转录、复制和修复的调控信息的组织和分类取决于核结构的组成部分。因此,有必要在核内微环境的背景下了解细胞过程,这些微环境调节转录、复制和修复机制的集中组装,并促进这些基本过程的协调。在这里,我们讨论核解剖如何支持组合控制调节蛋白招募的时间和空间协调。
The organization and sorting of regulatory information for transcription, replication and repair depends on components of nuclear architecture. It is necessary, therefore, to understand cellular processes within the context of intranuclear microenvironments that mediate the focal assembly of the machinery for transcription, replication and repair and which facilitate the orchestration of these essential processes. Here, we discuss how nuclear anatomy supports the temporal and spatial coordination of regulatory protein recruitment for combinatorial control.
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