Sulforaphane as a potential protective phytochemical against neurodegenerative diseases.
Sulforaphane as a potential protective phytochemical against neurodegenerative diseases.
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硫烷作为针对神经退行性疾病的潜在保护性植物化学。
DOI：
10.1155/2013/415078
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发表时间：
2013
影响因子：
--
通讯作者：
Hrelia P
中科院分区：
文献类型：
--
作者：
Tarozzi A;Angeloni C;Malaguti M;Morroni F;Hrelia S;Hrelia P
多种急性和慢性神经退行性疾病，包括缺血性/创伤性脑损伤、阿尔茨海默病和帕金森病，都有共同的特征，如氧化应激、错误折叠的蛋白质、兴奋性毒性、炎症和神经元损失。 由于没有药物可以预防这些神经系统疾病的进展，因此有人提出使用植物化学物质的干预策略作为替代治疗形式。在植物化学物质中，异硫氰酸萝卜硫素源自主要存在于甘蓝类蔬菜中的芥子油苷萝卜硫苷的水解，在多项体外和体内研究中已证明具有神经保护作用。特别是，有证据表明萝卜硫素的有益作用主要归因于其激活 Nrf2/ARE 途径的特殊能力。因此，萝卜硫素似乎是一种具有神经保护特性的有前途的化合物，可能在预防神经退行性变方面发挥重要作用。
A wide variety of acute and chronic neurodegenerative diseases, including ischemic/traumatic brain injury, Alzheimer's disease, and Parkinson's disease, share common characteristics such as oxidative stress, misfolded proteins, excitotoxicity, inflammation, and neuronal loss. As no drugs are available to prevent the progression of these neurological disorders, intervention strategies using phytochemicals have been proposed as an alternative form of treatment. Among phytochemicals, isothiocyanate sulforaphane, derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, has demonstrated neuroprotective effects in several in vitro and in vivo studies. In particular, evidence suggests that sulforaphane beneficial effects could be mainly ascribed to its peculiar ability to activate the Nrf2/ARE pathway. Therefore, sulforaphane appears to be a promising compound with neuroprotective properties that may play an important role in preventing neurodegeneration.
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DOI：
10.1158/1940-6207.capr-10-0296
发表时间：
2011-03
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Egner PA;Chen JG;Wang JB;Wu Y;Sun Y;Lu JH;Zhu J;Zhang YH;Chen YS;Friesen MD;Jacobson LP;Muñoz A;Ng D;Qian GS;Zhu YR;Chen TY;Botting NP;Zhang Q;Fahey JW;Talalay P;Groopman JD;Kensler TW
通讯作者：
Kensler TW
影响因子：
2.5
作者：
Dash PK;Zhao J;Orsi SA;Zhang M;Moore AN
通讯作者：
Moore AN
影响因子：
6.2
作者：
Danilov, Camelia A.;Chandirasekaran, Krish;Racz, Jennifer;Soane, Lucian;Zielke, Carol;Fiskum, Gary
通讯作者：
Fiskum, Gary
影响因子：
56.9
作者：
Conway, KA;Rochet, JC;Lansbury, PT
通讯作者：
Lansbury, PT
影响因子：
4.2
作者：
Cooper, DA;Webb, DR;Peters, JC
通讯作者：
Peters, JC