m6A modification-mediated lncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability.
m6A modification-mediated lncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability.
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m6A 修饰介导的 lncRNA TP53TG1 通过调节 CIP2A 稳定性抑制胃癌进展
作者：
长链非编码rna （lncrna）与多种类型的癌症有关。然而，许多lncrna在肿瘤进展中的确切作用尚不清楚。在本研究中，我们发现lncRNA TP53TG1在胃癌（GC）中表达下调，并发挥抑癌作用。此外，TP53TG1的低表达与GC患者的低生存率显著相关。TP53TG1抑制胃癌细胞的增殖、转移和细胞周期进程，促进胃癌细胞凋亡。m6A修饰位点在TP53TG1上非常丰富，去甲基化酶ALKBH5降低了TP53TG1的稳定性并下调了其表达。TP53TG1与癌性蛋白磷酸酶2A （CIP2A）抑制剂相互作用，触发其泛素化介导的降解，从而抑制PI3K/AKT通路。这些结果表明TP53TG1在抑制GC的进展中起着重要作用，为GC的治疗提供了一个重要的靶点。
Long noncoding RNAs (lncRNAs) are associated with various types of cancer. However, the precise roles of many lncRNAs in tumor progression remain unclear. In this study, we found that the expression of the lncRNA TP53TG1 was downregulated in gastric cancer (GC) and it functioned as a tumor suppressor. In addition, low TP53TG1 expression was significantly associated with poor survival in patients with GC. TP53TG1 inhibited the proliferation, metastasis, and cell cycle progression of GC cells, while it promoted their apoptosis. m6A modification sites are highly abundant on TP53TG1, and demethylase ALKBH5 reduces TP53TG1 stability and downregulates its expression. TP53TG1 interacts with cancerous inhibitor of protein phosphatase 2A (CIP2A) and triggers its ubiquitination‐mediated degradation, resulting in the inhibition of the PI3K/AKT pathway. These results suggest that TP53TG1 plays an important role in inhibiting the progression of GC and provides a crucial target for GC treatment.
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DOI：
10.1002/cac2.12193
发表时间：
2021-08
期刊：
Cancer communications (London, England)
影响因子：
--
作者：
Wang FH;Zhang XT;Li YF;Tang L;Qu XJ;Ying JE;Zhang J;Sun LY;Lin RB;Qiu H;Wang C;Qiu MZ;Cai MY;Wu Q;Liu H;Guan WL;Zhou AP;Zhang YJ;Liu TS;Bi F;Yuan XL;Rao SX;Xin Y;Sheng WQ;Xu HM;Li GX;Ji JF;Zhou ZW;Liang H;Zhang YQ;Jin J;Shen L;Li J;Xu RH
通讯作者：
Xu RH
DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Anastasiadou E;Jacob LS;Slack FJ
通讯作者：
Slack FJ
长链非编码 RNA 在癌症中的作用、功能和机制。
DOI：
10.1016/j.gpb.2015.09.006
发表时间：
2016-02
期刊：
Genomics, proteomics & bioinformatics
影响因子：
--
作者：
Fang Y;Fullwood MJ
通讯作者：
Fullwood MJ
影响因子：
14.9
作者：
Oerum S;Meynier V;Catala M;Tisné C
通讯作者：
Tisné C
影响因子：
5.2
作者：
Shin TJ;Lee KH;Cho JY
通讯作者：
Cho JY