Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.
Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.
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DOI：
10.1517/17425255.2011.532787
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发表时间：
2011-01
影响因子：
4.3
通讯作者：
Malhotra AK
中科院分区：
文献类型：
--
作者：
Zhang JP;Malhotra AK
抗精神病药物是精神分裂症的主要治疗药物，其临床疗效和副作用存在较大的个体差异。药物遗传学提供了一个有价值的工具，通过根据一个人的遗传标记定制治疗来实现个性化药物的承诺。本文回顾了20世纪90年代初至2010年的药物遗传学文献，重点介绍了药物作用的两个方面：药代动力学和药效学。讨论了多巴胺和5-羟色胺等神经递质受体的遗传变异和药物代谢途径与临床药物反应和副作用的关系。读者应了解药物遗传学研究的最新证据，并熟悉该领域面临的问题和挑战。抗精神病药物的药物遗传学研究既有希望也有挑战。有一致的证据表明，一些基因变异会影响临床反应和副作用。然而，显然需要更多专门为测试药物遗传学假说而设计的研究来推动这一领域的发展。
Antipsychotic drug is the mainstay of treatment for schizophrenia, and there are large inter-individual differences is clinical response and side effects. Pharmacogenetics provides a valuable tool to fulfill the promise of personalized medicine by tailoring treatment based on one's genetic markers. This article reviews the pharmacogenetic literature from early 1990s to 2010, focusing on two aspects of drug action: pharmacokinetics and pharmacodynamics. Genetic variants in the neurotransmitter receptors including dopamine and serotonin, and metabolic pathways of drugs including CYP2D6 and COMT, were discussed in association with clinical drug response and side effects. Readers are expected to learn the up-to-date evidence in pharmacogenetic research, and to gain familiarity to the issues and challenges facing the field. Pharmacogenetic research of antipsychotic drugs is both promising and challenging. There is consistent evidence that some genetic variants can affect clinical response and side effects. However, more studies that are designed specifically to test pharmacogenetic hypotheses are clearly needed to advance the field.
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影响因子：
3.4
作者：
Chen, Shih-Fen;Shen, Yu-Chih;Chen, Chia-Hsiang
通讯作者：
Chen, Chia-Hsiang
影响因子：
10.6
作者：
Chen, CH;Wei, FC;Hsiao, KJ
通讯作者：
Hsiao, KJ
影响因子：
10.6
作者：
Barnett, Jennifer H.;Scoriels, Linda;Munafo, Marcus R.
通讯作者：
Munafo, Marcus R.
影响因子：
4.5
作者：
Bakker, PR;van Harten, PN;van Os, J
通讯作者：
van Os, J
影响因子：
11
作者：
Basile, VS;Ozdemir, V;Kennedy, JL
通讯作者：
Kennedy, JL