National Antimicrobial Resistance Monitoring System: Two Decades of Advancing Public Health Through Integrated Surveillance of Antimicrobial Resistance.
National Antimicrobial Resistance Monitoring System: Two Decades of Advancing Public Health Through Integrated Surveillance of Antimicrobial Resistance.
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DOI：
10.1089/fpd.2017.2283
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发表时间：
2017-10
影响因子：
2.8
通讯作者：
McDermott PF
中科院分区：
文献类型：
--
作者：
Karp BE;Tate H;Plumblee JR;Dessai U;Whichard JM;Thacker EL;Hale KR;Wilson W;Friedman CR;Griffin PM;McDermott PF
耐药细菌感染对全球公共卫生构成严重和日益严重的威胁。在这篇综述中，我们描述了国家抗菌药物耐药性监测系统（NARMS）在提供有助于解决耐药性问题的数据方面的作用，并展示了这样一个项目如何对公共卫生产生广泛的积极影响。NARMS成立于20年前，旨在帮助评估美国食用动物生产中使用抗菌药物对人类健康的影响。NARMS是美国疾病控制和预防中心、美国食品和药物管理局、美国农业部以及州和地方卫生部门之间的合作，它采用综合的“同一健康”方法来监测人类、零售肉类和食用动物肠道细菌的抗菌素耐药性。NARMS通过扩大监测集水区、检查新的分离源、添加细菌、调整采样方案和修改测试的抗菌剂来适应不断变化的需求和威胁。NARMS数据不仅对于确保批准用于食用动物的抗菌药物以对人类健康安全的方式使用至关重要，而且还有助于解决更广泛的食品安全优先事项。NARMS监测、应用研究和爆发分离株检测提供了关于耐药肠道细菌出现的数据;耐药的遗传机制;细菌种群在人类、食品和食用动物中的移动;以及耐药和易感感染的来源和结果。这些数据可用于指导和评估以科学为基础的政策、监管行动、抗菌药物管理举措以及旨在保持药物有效性、改善患者预后和预防感染的其他公共卫生工作的影响。随着时间的推移，NARMS已经做出了许多改进，该计划将继续适应新出现的耐药性威胁，临床诊断实践的变化以及新技术，如全基因组测序。
Drug-resistant bacterial infections pose a serious and growing public health threat globally. In this review, we describe the role of the National Antimicrobial Resistance Monitoring System (NARMS) in providing data that help address the resistance problem and show how such a program can have broad positive impacts on public health. NARMS was formed two decades ago to help assess the consequences to human health arising from the use of antimicrobial drugs in food animal production in the United States. A collaboration among the Centers for Disease Control and Prevention, the U.S. Food and Drug Administration, the United States Department of Agriculture, and state and local health departments, NARMS uses an integrated “One Health” approach to monitor antimicrobial resistance in enteric bacteria from humans, retail meat, and food animals. NARMS has adapted to changing needs and threats by expanding surveillance catchment areas, examining new isolate sources, adding bacteria, adjusting sampling schemes, and modifying antimicrobial agents tested. NARMS data are not only essential for ensuring that antimicrobial drugs approved for food animals are used in ways that are safe for human health but they also help address broader food safety priorities. NARMS surveillance, applied research studies, and outbreak isolate testing provide data on the emergence of drug-resistant enteric bacteria; genetic mechanisms underlying resistance; movement of bacterial populations among humans, food, and food animals; and sources and outcomes of resistant and susceptible infections. These data can be used to guide and evaluate the impact of science-based policies, regulatory actions, antimicrobial stewardship initiatives, and other public health efforts aimed at preserving drug effectiveness, improving patient outcomes, and preventing infections. Many improvements have been made to NARMS over time and the program will continue to adapt to address emerging resistance threats, changes in clinical diagnostic practices, and new technologies, such as whole genome sequencing.
影响因子：
2
作者：
Bae, Dongryeoul;Kweon, Ohgew;Khan, Ashraf A.
通讯作者：
Khan, Ashraf A.
影响因子：
11.8
作者：
Collignon, Peter C.;Conly, John M.;Aidara-Kane, Awa
通讯作者：
Aidara-Kane, Awa