Surveillance scanning of children with medulloblastoma.
Surveillance scanning of children with medulloblastoma.
复制标题
髓母细胞瘤儿童的监测扫描。
DOI：
10.1056/nejm199403313301303
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Lange,BJ
中科院分区：
文献类型：
--
作者：
Torres,CF;Rebsamen,S;Silber,JH;Sutton,LN;Bilaniuk,LT;Zimmerman,RA;Goldwein,JW;Phillips,PC;Lange,BJ
背景髓母细胞瘤患儿的标准随访包括定期的临床评估和使用计算机断层扫描或磁共振成像对中枢神经系统进行监测扫描。评估和扫描评估肿瘤对治疗的反应，检测任何疾病复发，并监测任何治疗并发症。我们比较了有效性的定期病史和体格检查的监测扫描在检测复发tumors.MethodsWe回顾了病历，包括794扫描报告或扫描，86例儿童后颅窝髓母细胞瘤谁定期随访1980年和1991年之间。复发性肿瘤被归类为有症状的，如果神经影像学研究已提示的临床症状或体征和放射学检查，如果肿瘤已被检测到的成像在一个无症状patient.Results23的86名儿童（27%）有肿瘤复发。4例复发（17%）仅在扫描时检测到，19例（83%）与前一次扫描后4个月的中位症状有关。肿瘤复发后的中位生存期和生存范围分别为5个月和<1至38个月（对于症状性复发）和20个月和10至32个月（对于放射学复发）（P = 0.03）。复发后无患者存活。通过扫描检测到的肿瘤复发患者的生存时间较长，这很可能反映了患者人数少，以及与screen.ConclusionsAmong儿童髓母细胞瘤，监测扫描的临床价值不大。扫描发现少数复发，复发患者无一存活。
BackgroundThe standard follow-up care for children with medulloblastoma includes regular clinical evaluations and surveillance scanning of the central nervous system with computed tomography or magnetic resonance imaging. The evaluations and scanning assess the response of the tumor to treatment, detect any recurrence of disease, and monitor any complications of treatment. We compared the effectiveness of a periodic history taking and physical examination with that of surveillance scanning in detecting recurrent tumors.MethodsWe reviewed the medical records, including 794 scanning reports or scans, of 86 children with posterior fossa medulloblastoma who were followed regularly between 1980 and 1991. Recurrent tumors were classified as symptomatic if neuroimaging studies had been prompted by clinical symptoms or signs and as radiographic if the tumor had been detected by imaging in an asymptomatic patient.ResultsTwenty-three of the 86 children (27 percent) had a recurrence of tumor. Four recurrences (17 percent) were detected on scanning only, and 19 (83 percent) were associated with symptoms arising a median of four months after the previous scan. The median and range of survival after a recurrence of the tumor were 5 months and <1 to 38 months, respectively, for a symptomatic recurrence and 20 months and 10 to 32 months, respectively, for a radiographic recurrence (P = 0.03). No patient survived after a recurrence. The longer survival of patients with recurrent tumors detected by scanning most likely reflects the small number of patients and lead-time and length biases associated with screening.ConclusionsAmong children with medulloblastoma, surveillance scanning is of little clinical value. Scanning detected a minority of recurrences, and no patient who had a recurrence survived.
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脑研究 346-1。
DOI：
--
发表时间：
--
期刊：
影响因子：
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作者：
通讯作者：
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通过常规骨髓抽吸诊断患有急性淋巴细胞白血病的儿童出现意外骨髓复发的情况来自儿童癌症研究小组的报告
DOI：
10.1016/s0140-6736(84)91819-1
发表时间：
1984
期刊：
The Lancet
影响因子：
--
作者：
PaulC.J. Rogers;P. Coccia;S. Siegel;W. Bleyer;J. Lukens;H. Sather;D. Hammond
通讯作者：
D. Hammond
低剂量颅脊髓放射治疗联合化疗治疗 5 岁以下原始神经外胚层肿瘤儿童的初步研究结果
影响因子：
6.2
作者：
J. Goldwein;J. Radcliffe;R. Packer;L. Sutton;B. Lange;L. Rorke;G. D'angio
通讯作者：
G. D'angio
影响因子：
11.2
作者：
J. Gregory Caincross;J. H. Pexman;M. Rathbone;Ronaldo F. DelMaestro
通讯作者：
Ronaldo F. DelMaestro
小儿脑肿瘤的医学成像。
DOI：
10.1159/000413663
发表时间：
1987
期刊：
Progress in experimental tumor research
影响因子：
--
作者：
R. Zimmerman;L. Bilaniuk;L. Schut;R. Packer;L. Sutton;D. Bruce
通讯作者：
D. Bruce