A Hydrogel Meniscal Replacement: Knee Joint Pressure and Distribution in an Ovine Model Compared to Native Tissue.
A Hydrogel Meniscal Replacement: Knee Joint Pressure and Distribution in an Ovine Model Compared to Native Tissue.
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DOI：
10.1007/s10439-018-2069-8
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发表时间：
2018-11
影响因子：
3.8
通讯作者：
Haut Donahue TL
中科院分区：
文献类型：
--
作者：
Fischenich KM;Pauly HM;Lewis JT;Bailey TS;Haut Donahue TL
将天然绵羊膝关节半月板的压力分布与内侧半月板切除和三种治疗条件进行了比较，包括天然组织的缝合再附着、同种异体移植和新型热塑性弹性体水凝胶(TPE)结构。本研究的目的是评估一种新型热塑性弹性体水凝胶结构在恢复关节压力和分布方面的效果。分别在屈曲45°、60°、75°、0~181 kg时，对肢体进行单轴压缩。内侧半月板切除术减少了约50%的接触面积，并使内侧半关节的平均和最大压力读数增加了一倍。在这项研究中测试的任何治疗条件都不能将关节内侧接触面积和压力完全恢复到本地条件。半月板切除后，侧方接触面积减少，压力增加；在某种程度上，包括新型TPE水凝胶置换在内的所有再附着和置换条件都有助于恢复侧向压力。尽管TPE结构在内侧间隙的表现不如预期，但它的表现与外侧的其他重附着和替换方案一样好，如果不是更好的话。需要进一步的工作来确定最佳的锚固和附着方法。
Pressure distribution of the native ovine knee meniscus was compared to a medial meniscectomy and three treatment conditions including a suture reattachment of the native tissue, an allograft, and a novel thermoplastic elastomer hydrogel (TPE) construct. The objective of this study was to assess the efficacy of a novel TPE hydrogel construct at restoring joint pressure and distribution. Limbs were loaded in uniaxial compression at 45°, 60°, and 75° flexion and from 0–181kg. The medial meniscectomy decreased contact area by approximately 50% and doubled the mean and maximum pressure reading for the medial hemijoint. No treatment condition tested within this study was able to fully restore medial joint contact area and pressures to the native condition. A decrease in lateral contact area and increase in pressures with the meniscectomy was also seen; and to some degree, all reattachment and replacement conditions including the novel TPE hydrogel replacement helped to restore lateral pressures. Although the TPE construct did not perform as well as hoped in the medial compartment, it performed as well as, if not better, than the other reattachment and replacement options in the lateral. Further work is necessary to determine the best anchoring and attachment methods.
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影响因子：
2.4
作者：
Cottrell, Jocelyn M.;Scholten, Paul;Maher, Suzanne A.
通讯作者：
Maher, Suzanne A.
DOI：
10.1002/jbm.820290706
发表时间：
1995-07-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
JOSHI, MD;SUH, JK;WOO, SLY
通讯作者：
WOO, SLY
DOI：
10.1115/1.3138409
发表时间：
1983-01-01
影响因子：
1.7
作者：
AHMED, AM;BURKE, DL
通讯作者：
BURKE, DL
影响因子：
2.4
作者：
Harris, ML;Morberg, P;Walsh, WR
通讯作者：
Walsh, WR
影响因子：
2.3
作者：
Bouyarmane, H.;Beaufils, P.;Verdonk, R.
通讯作者：
Verdonk, R.