Characteristics of mental health implications and plasma metabolomics in patients recently recovered from COVID-19.
Characteristics of mental health implications and plasma metabolomics in patients recently recovered from COVID-19.
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DOI：
10.1038/s41398-021-01426-3
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发表时间：
2021-05-21
影响因子：
6.8
通讯作者：
Jin Y
中科院分区：
文献类型：
--
作者：
Yang L;Zhou M;Li L;Luo P;Fan W;Xu J;Chen Q;Pan F;Lei P;Zheng C;Jin Y
本研究旨在探讨新冠肺炎康复期患者脑白质(WM)改变与心理健康状况及代谢的关系。纳入2020年4月至2020年6月期间28例新冠肺炎康复者和27例健康对照。收集两组的人口学数据、心理健康评分、弥散张量成像(DTI)数据和血浆代谢组学数据，并进行比较。DTI数据分析采用基于区域的空间统计和图论方法。对血浆进行非靶向代谢组学分析。对这些特征进行了相关性分析。新冠肺炎康复者表现为弥漫脑区各向异性分数降低，平均扩散系数和放射状扩散系数增加，枕上回整体有效率显著降低，最短路径延长，结节局部有效率降低(ALL，P <； 005，Bonferroni校正)。我们的结果还显示，即使在出院后3个月，新冠肺炎康复者的血浆代谢谱也有显著差异，这主要与嘌呤途径、氨基酸、血脂和胺代谢有关。恢复期患者某些脑白质改变区域与不同代谢物及心理健康评分有显著相关性。我们观察到WM完整性和血浆代谢组学的多重变化，这可能解释了新冠肺炎康复患者心理健康恶化的原因。这些发现可能为新冠肺炎康复者的心理健康评估提供潜在的生物标志物，并为新的治疗方法提供潜在的靶点。
This study aimed to explore the associations between cerebral white matter (WM) alterations, mental health status, and metabolism in recovered COVID-19 patients. We included 28 recovered COVID-19 patients and 27 healthy controls between April 2020 and June 2020. Demographic data, the mental health scores, diffusion-tensor imaging (DTI) data, and plasma metabolomics were collected and compared between the two groups. Tract-based spatial statistics and graph theory approaches were used for DTI data analysis. Untargeted metabolomics analysis of the plasma was performed. Correlation analyses were performed between these characteristics. Recovered COVID-19 patients showed decreased fractional anisotropy, increased mean diffusivity and radial diffusivity values in widespread brain regions, and significantly lower global efficiency, longer shortest path length, and less nodal local efficiency in superior occipital gyrus (all, P < 0.05, Bonferroni corrected). Our results also demonstrated significantly different plasma metabolic profiling in recovered COVID-19 patients even at 3 months after their hospital discharge, which was mainly related to purine pathways, amino acids, lipids, and amine metabolism. Certain regions with cerebral WM alterations in the recovered patients showed significant correlations with different metabolites and the mental health scores. We observed multiple alterations in both WM integrity and plasma metabolomics that may explain the deteriorated mental health of recovered COVID-19 patients. These findings may provide potential biomarkers for the mental health evaluation for the recovered COVID-19 patients and potential targets for novel therapeutics.
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影响因子：
10.6
作者：
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通讯作者：
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DOI：
10.1111/j.1460-9568.2011.07936.x
发表时间：
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