Emerging Insights into Noncanonical Inflammasome Recognition of Microbes.
Emerging Insights into Noncanonical Inflammasome Recognition of Microbes.
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DOI：
10.1016/j.jmb.2017.10.003
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发表时间：
2018-01-19
影响因子：
5.6
通讯作者：
Rathinam VAK
中科院分区：
文献类型：
--
作者：
Russo AJ;Behl B;Banerjee I;Rathinam VAK
Inflammasomes are cytosolic multi-molecular complexes that sense intracellular microbial danger signals and metabolic perturbations. Inflammasome activation leads to the activation of caspase-1 and the release of pro-inflammatory cytokines IL-1β and IL-18 accompanied by cell death. An inflammasome-based surveillance machinery for Gram-negative bacterial infections has been recently discovered. This noncanonical inflammasome relies on sensing the cytosolic presence of lipopolysaccharide (LPS) of Gram-negative bacteria via inflammatory caspases such as caspase-4, -5, and -11. This Review discusses the recent findings related to the mechanism of activation of the noncanonical inflammasome and its biological functions.
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影响因子：
32.4
作者：
Choi, Hae Woong;Bowen, Samantha E.;Miao, Yuxuan;Chan, Cheryl Y.;Miao, Edward A.;Abrink, Magnus;Moeser, Adam J.;Abraham, Soman N.
通讯作者：
Abraham, Soman N.
DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
作者：
Aglietti, Robin A.;Estevez, Alberto;Dueber, Erin C.
通讯作者：
Dueber, Erin C.
影响因子：
4.4
作者：
Bian, Zong-Mei;Elner, Susan G.;Elner, Victor M.
通讯作者：
Elner, Victor M.
DOI：
10.1126/science.1240988
发表时间：
2013-09-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hagar JA;Powell DA;Aachoui Y;Ernst RK;Miao EA
通讯作者：
Miao EA
影响因子：
64.8
作者：
Ding, Jingjin;Wang, Kun;Shao, Feng
通讯作者：
Shao, Feng