Handgrip strength and subclinical carotid atherosclerosis in relation to platelet levels among hypertensive elderly Japanese.
Handgrip strength and subclinical carotid atherosclerosis in relation to platelet levels among hypertensive elderly Japanese.
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DOI：
10.18632/oncotarget.20618
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发表时间：
2017-09-19
期刊：
影响因子：
--
通讯作者：
Maeda T
中科院分区：
文献类型：
--
作者：
Shimizu Y;Sato S;Koyamatsu J;Yamanashi H;Nagayoshi M;Kadota K;Kawashiri SY;Inoue K;Nagata Y;Maeda T
动脉粥样硬化相关的微血管内皮破坏加重高血压和肌肉减少症;动脉粥样硬化是众所周知的血管内皮损伤的生物学反应。因此，老年高血压患者中动脉粥样硬化的患病率可能部分表明存在对内皮损伤的适当反应。我们对795名年龄在60-89岁的日本老年高血压患者进行了一项横断面研究。由于血小板水平是血管修复活性的指标，因此按血小板计数对受试者进行分层。对于血小板计数较低的受试者，未观察到握力与亚临床颈动脉粥样硬化（颈动脉内膜中层厚度（CIMT）≥ 1.1 mm）之间存在显著相关性，而对于血小板计数较高的受试者，观察到握力与亚临床颈动脉粥样硬化之间存在显著正相关性。对于亚临床颈动脉粥样硬化的调整优势和95%置信区间为1个标准差增量的握力为0.86（0.61，1.22）的受试者血小板较低和1.82（1.26，2.64）的受试者血小板较高。在老年高血压患者中，握力和亚临床颈动脉粥样硬化之间存在正相关，血小板计数较高，但不较低。这些结果使我们推测，对预防肌肉减少症（保持握力）有有益影响的受试者可能具有导致动脉粥样硬化的主动内皮修复能力。
Age-related disruption of microvascular endothelium exacerbates hypertension and sarcopenia; and atherosclerosis is a well-known biological response to vascular endothelial injury. Therefore, prevalence of atherosclerosis among hypertensive elderly subjects may partly indicate the presence of an appropriate response to endothelial injury. We conducted a cross-sectional study of 795 elderly hypertensive Japanese subjects aged 60-89 years. Since platelet level is an indicator of vascular repair activity, subjects were stratified by platelet counts. No significant association between handgrip strength and subclinical carotid atherosclerosis (carotid intima-media thickness (CIMT) ≥1.1mm) was observed for subjects with lower platelet counts, while a significant positive association was observed for subjects with higher platelets. Adjusted odds and 95% confidence intervals of subclinical carotid atherosclerosis for 1 standard deviation increments in handgrip strength were 0.86 (0.61, 1.22) for subjects with lower platelets and 1.82 (1.26, 2.64) for subjects with higher platelets. A positive association between handgrip strength and subclinical carotid atherosclerosis exists in hypertensive elderly subjects with higher, but not lower, platelet counts. These results lead us to speculate that subjects with a beneficial influence on prevention of sarcopenia (maintenance of handgrip strength) may possess the capacity of active endothelial repair that causes atherosclerosis.
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影响因子：
20.3
作者：
Shi, Q;Rafii, S;Hammond, WP
通讯作者：
Hammond, WP
影响因子：
20.3
作者：
Majka, M;Janowska-Wieczorek, A;Ratajczak, MZ
通讯作者：
Ratajczak, MZ
DOI：
10.1196/annals.1349.011
发表时间：
2005-01-01
期刊：
HEMATOPOIETIC STEM CELLS V
影响因子：
--
作者：
Seitz, G;Boehmler, AM;Möhle, R
通讯作者：
Möhle, R
影响因子：
16.2
作者：
KAWAMORI, R;YAMASAKI, Y;KAMADA, T
通讯作者：
KAMADA, T
影响因子：
4.3
作者：
Gunn, N;Damon, L;Linker, C
通讯作者：
Linker, C