Challenges and promise of targeting miRNA in rheumatic diseases: a computational approach to identify miRNA association with cell types, cytokines, and disease mechanisms.
Challenges and promise of targeting miRNA in rheumatic diseases: a computational approach to identify miRNA association with cell types, cytokines, and disease mechanisms.
复制标题
风湿性疾病中靶向miRNA的挑战和前景：识别miRNA与细胞类型，细胞因子和疾病机制相关性的计算方法。
DOI：
10.3389/fimmu.2023.1322806
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发表时间：
2023
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
MicroRNAs(MiRNAs)是一种小的非编码RNA，它在转录后水平改变靶基因的表达，影响新陈代谢、细胞分化、增殖、细胞存活和细胞死亡的各种结果。MiRNA表达异常与多种风湿性疾病有关，包括强直性脊柱炎(AS)、痛风、幼年特发性关节炎(JIA)、骨性关节炎(OA)、银屑病关节炎、类风湿性关节炎(RA)、干燥综合征、系统性红斑狼疮(SLE)和系统性硬化症。在这篇综述中，我们使用开放源码编程语言PowerShell，扫描了大量现有的PubMed上关于这九种疾病中miRNAs的主要研究出版物，以识别和统计单个miRNAs和疾病名称的独特共现。这些计数被用来根据它们在每种风湿性疾病中的研究量对前七个最相关的免疫微受体进行排名。还筛选了单个miRNAs，并将其与风湿性疾病相关的免疫细胞、细胞因子和病理过程的名称一起公布。这些事件被列成矩阵，以确定与研究相关的热点。基于这些信息，我们总结了排名前三位的miRNAs-miR-146、miR-155和miR-21的基本和临床发现，它们的相关性跨越了多种风湿性疾病。此外，我们强调了每种疾病的一些独特的miRNAs，以及为什么一些风湿性疾病缺乏在这个新兴的表观遗传学领域的研究。随着大量关于miRNAs在风湿性疾病中的发表，这篇综述成为指导研究人员根据已有的关于miRNAs参与疾病发病机制的现有知识来选择miRNAs的“相关性查找器”。这种方法适用于其他疾病背景，最终目标是开发基于miRNA的疗法。
MicroRNAs (miRNAs) are small non-coding RNAs that alter the expression of target genes at the post-transcriptional level, influencing diverse outcomes in metabolism, cell differentiation, proliferation, cell survival, and cell death. Dysregulated miRNA expression is implicated in various rheumatic conditions, including ankylosing spondylitis (AS), gout, juvenile idiopathic arthritis (JIA), osteoarthritis (OA), psoriatic arthritis, rheumatoid arthritis (RA), Sjogren’s syndrome, systemic lupus erythematosus (SLE) and systemic sclerosis. For this review, we used an open-source programming language- PowerShell, to scan the massive number of existing primary research publications on PubMed on miRNAs in these nine diseases to identify and count unique co-occurrences of individual miRNAs and the disease name. These counts were used to rank the top seven most relevant immuno-miRs based on their research volume in each rheumatic disease. Individual miRNAs were also screened for publication with the names of immune cells, cytokines, and pathological processes involved in rheumatic diseases. These occurrences were tabulated into matrices to identify hotspots for research relevance. Based on this information, we summarize the basic and clinical findings for the top three miRNAs — miR-146, miR-155, and miR-21 — whose relevance spans across multiple rheumatic diseases. Furthermore, we highlight some unique miRNAs for each disease and why some rheumatic conditions lack research in this emerging epigenetics field. With the overwhelming number of publications on miRNAs in rheumatic diseases, this review serves as a ‘relevance finder’ to guide researchers in selecting miRNAs based on the compiled existing knowledge of their involvement in disease pathogenesis. This approach applies to other disease contexts with the end goal of developing miRNA-based therapeutics.
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基于文献计量分析，在骨关节炎中揭示了十个热点microRNA及其潜在的软骨细胞的潜在靶标。
影响因子：
--
作者：
Hu, Wei-Shang;Zhang, Qi;Li, Si-Hui;Ai, Shuang-Chun;Wu, Qiao-Feng
通讯作者：
Wu, Qiao-Feng
影响因子：
4.6
作者：
Galatenko VV;Galatenko AV;Samatov TR;Turchinovich AA;Shkurnikov MY;Makarova JA;Tonevitsky AG
通讯作者：
Tonevitsky AG
影响因子：
7.3
作者：
通讯作者：
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DOI：
10.31662/jmaj.2019-0020
发表时间：
2020-01-15
期刊：
JMA journal
影响因子：
--
作者：
Honda S;Katsumata Y;Karasawa K;Yamanaka H;Harigai M
通讯作者：
Harigai M
影响因子：
2.6
作者：
Yao N;Peng S;Wu H;Liu W;Cai D;Huang D
通讯作者：
Huang D