Sjögren's syndrome: novel insights from proteomics and miRNA expression analysis.
Sjögren's syndrome: novel insights from proteomics and miRNA expression analysis.
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DOI：
10.3389/fimmu.2023.1183195
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发表时间：
2023
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
Sjögren综合征（SS）是一种系统性自身免疫性疾病，它影响外分泌腺，导致腺体功能障碍，特别是口腔和眼睛干燥的症状。SS的病因尚不清楚，该病缺乏明显的临床特征。目前的诊断工作是复杂的、侵入性的，而且往往很耗时。因此，有一个新兴的需求，即识别疾病特异性的，理想的，非侵入性的免疫和分子生物标志物，可以简化诊断过程，允许患者分层，并协助监测SS的病程和治疗干预的结果。本系统综述讨论了在这方面使用蛋白质组学和mirna表达谱分析。在272篇被鉴定和108篇综述中，共有42篇关于蛋白质组学的论文和23篇关于唾液、血液和唾液腺组织中miRNA分析的论文被纳入本综述。总体而言，蛋白质组学和miRNA研究显示，候选生物标志物蛋白和miRNA存在相当大的差异，这很可能是由于样本量、处理和分析方法的差异，但也反映了SS的复杂性和患者异质性。然而，有趣的新知识已经出现，需要进一步验证它们作为SS生物标志物的潜在作用。
Sjögren’s syndrome (SS) is a systemic autoimmune disease, which affects the exocrine glands leading to glandular dysfunction and, particularly, symptoms of oral and ocular dryness. The aetiology of SS remains unclear, and the disease lacks distinctive clinical features. The current diagnostic work-up is complex, invasive and often time-consuming. Thus, there is an emerging need for identifying disease-specific and, ideally, non-invasive immunological and molecular biomarkers that can simplify the diagnostic process, allow stratification of patients, and assist in monitoring the disease course and outcome of therapeutic intervention in SS. This systematic review addresses the use of proteomics and miRNA-expression profile analyses in this regard. Out of 272 papers that were identified and 108 reviewed, a total of 42 papers on proteomics and 23 papers on miRNA analyses in saliva, blood and salivary gland tissue were included in this review. Overall, the proteomic and miRNA studies revealed considerable variations with regard to candidate biomarker proteins and miRNAs, most likely due to variation in sample size, processing and analytical methods, but also reflecting the complexity of SS and patient heterogeneity. However, interesting novel knowledge has emerged and further validation is needed to confirm their potential role as biomarkers in SS.
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影响因子：
4.4
作者：
Hall, Steven C.;Hassis, Maria E.;Williams, Katherine E.;Albertolle, Matthew E.;Prakobphol, Akrapom;Dykstra, Andrew B.;Laurance, Megan;Ona, Katherine;Niles, Richard K.;Prasad, Namrata;Gormley, Matthew;Shiboski, Caroline;Criswell, Lindsey A.;Witkowska, H. Ewa;Fisher, Susan J.
通讯作者：
Fisher, Susan J.
DOI：
10.4172/2157-7412.1000140
发表时间：
2013-06-15
期刊：
Journal of genetic syndromes & gene therapy
影响因子：
--
作者：
Gallo A;Martini D;Sernissi F;Giacomelli C;Pepe P;Rossi C;Riveros P;Mosca M;Alevizos I;Baldini C
通讯作者：
Baldini C
影响因子：
--
作者：
Hu, Shen;Zhou, Michael;Jiang, Jiang;Wang, Jianghua;Elashoff, David;Gorr, Sven;Michie, Sara A.;Spijkervet, Fred K. L.;Bootsma, Hendrika;Kallenberg, Cees G. M.;Vissink, Arjan;Horvath, Steve;Wong, David T.
通讯作者：
Wong, David T.
影响因子：
4.9
作者：
Aqrawi, Lara A.;Galtung, Hilde Kanli;Jensen, Janicke Liaaen
通讯作者：
Jensen, Janicke Liaaen
影响因子：
3.8
作者：
Baron, AC;DeCarlo, AA;Featherstone, JDB
通讯作者：
Featherstone, JDB