The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis.
The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis.
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DOI：
10.1016/j.bja.2023.03.008
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发表时间：
2023-06
影响因子：
9.8
通讯作者：
Colvin, Lesley A.
中科院分区：
文献类型：
--
作者：
Antoniou, Georgia;Lambourg, Emilie;Steele, J. Douglas;Colvin, Lesley A.
关键词：
不良的童年经历与多种疾病的增加有关，并对一生的身心健康造成影响。慢性疼痛通常与情绪障碍有关，例如重度抑郁症 (MDD)；两者都与不良的童年经历有关。目前尚不清楚不良童年经历对神经处理的影响如何影响慢性疼痛、抑郁症或两者的易感性，以及是否存在共同机制。我们的目的是通过系统评价和荟萃分析来评估患有慢性疼痛、重度抑郁症或两者兼而有之的受试者中与不良童年经历相关的中枢神经变化的证据。系统地搜索了电子数据库，以查找不良童年经历（包括慢性疼痛、MDD 或两者兼而有之）的神经影像学研究。两名独立审稿人筛选标题、摘要和全文，并评估质量。提取神经影像数据后，进行激活可能性估计荟萃分析，以确定与这些合并症相关的重要大脑区域。 2414 项研究中有 49 项符合资格，其中 43 项调查不良童年经历和 MDD，六项调查不良童年经历和慢性疼痛。没有人一起研究不良童年经历、慢性疼痛和抑郁症。在经历过不良童年经历的重度抑郁症患者中，在额上回、舌回、海马、岛叶、壳核、颞上回、颞下回和小脑前部发现了功能和结构性大脑异常。此外，在基于任务的功能性 MRI 研究中，还发现了患有 MDD 或慢性疼痛以及童年经历不良经历的患者的扣带回、顶下小叶和楔前叶的脑功能异常。我们发现，与没有不良童年经历的人相比，患有重度抑郁症或慢性疼痛的成年人，接触不良童年经历可能会导致不同的功能和结构改变。普洛斯彼罗 CRD42021233989。
Adverse childhood experiences have been linked to increased multimorbidity, with physical and mental health consequences throughout life. Chronic pain is often associated with mood disorders, such as major depressive disorder (MDD); both have been linked to adverse childhood experiences. It is unclear how the effect of adverse childhood experiences on neural processing impacts on vulnerability to chronic pain, MDD, or both, and whether there are shared mechanisms. We aimed to assess evidence for central neural changes associated with adverse childhood experiences in subjects with chronic pain, MDD, or both using systematic review and meta-analysis. Electronic databases were systematically searched for neuroimaging studies of adverse childhood experiences, with chronic pain, MDD, or both. Two independent reviewers screened title, abstracts, and full text, and assessed quality. After extraction of neuroimaging data, activation likelihood estimate meta-analysis was performed to identify significant brain regions associated with these comorbidities. Forty-nine of 2414 studies were eligible, of which 43 investigated adverse childhood experiences and MDD and six investigated adverse childhood experiences and chronic pain. None investigated adverse childhood experiences, chronic pain, and MDD together. Functional and structural brain abnormalities were identified in the superior frontal, lingual gyrus, hippocampus, insula, putamen, superior temporal, inferior temporal gyrus, and anterior cerebellum in patients with MDD exposed to adverse childhood experiences. In addition, brain function abnormalities were identified for patients with MDD or chronic pain and exposure to adverse childhood experiences in the cingulate gyrus, inferior parietal lobule, and precuneus in task-based functional MRI studies. We found that adverse childhood experiences exposure can result in different functional and structural brain alterations in adults with MDD or chronic pain compared with those without adverse childhood experiences. PROSPERO CRD42021233989.
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影响因子：
4.8
作者：
Eickhoff, Simon B.;Laird, Angela R.;Grefkes, Christian;Wang, Ling E.;Zilles, Karl;Fox, Peter T.
通讯作者：
Fox, Peter T.
影响因子：
4.3
作者：
Frost CP;Meyerand ME;Birn RM;Hoks RM;Walsh EC;Abercrombie HC
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影响因子：
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影响因子：
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11.2
作者：
BERTHIER, M;STARKSTEIN, S;LEIGUARDA, R
通讯作者：
LEIGUARDA, R