Childhood Emotional Abuse Moderates Associations Among Corticomotor White Matter Structure and Stress Neuromodulators in Women With and Without Depression.
Childhood Emotional Abuse Moderates Associations Among Corticomotor White Matter Structure and Stress Neuromodulators in Women With and Without Depression.
复制标题
DOI：
10.3389/fnins.2018.00256
复制
发表时间：
2018
影响因子：
4.3
通讯作者：
Abercrombie HC
中科院分区：
文献类型：
--
作者：
Frost CP;Meyerand ME;Birn RM;Hoks RM;Walsh EC;Abercrombie HC
发育过程中的不良行为会对神经、内分泌和对压力的行为反应产生持久的变化，并且与成人精神病理学的风险升高密切相关。虽然先前的逆境经历与交感神经系统（SNS）和下丘脑-垂体-肾上腺（HPA）轴活动的改变有关，但其潜在的神经通路尚不完全清楚。在一项双盲交叉研究中，我们使用扩散张量成像（DTI）来研究白色物质结构的变化是否可以预测早期逆境下HPA-SNS相互作用的差异。参与者包括74名女性，她们表现出广泛的抑郁症严重程度和/或儿童情感虐待（EA）。参与者参加了两个实验阶段，在此期间，他们被给予20毫克皮质醇（CORT）或安慰剂，90分钟后，在接受MRI扫描时观看充满情感的图片。在情绪化的图片观看后，我们立即收集唾液α-淀粉酶（sAA）来指示SNS激活。我们测试了EA是否缓和分数各向异性（FA），一个衡量白色物质纤维结构，和sAA之间的关系。在安慰剂条件下，对于具有最小EA历史的参与者，皮质运动预测中的较高FA与sAA呈负相关，而在严重EA的参与者中，相关性呈相反方向。CORT给药后，FA和sAA不相关，表明急性皮质醇升高期间的SNS音调可能取决于皮质运动投射以外的神经通路。结果表明，在基线水平，虽然不是在皮质醇升高，增加FA在这些道与SNS活动水平较低的妇女与最小的EA，但不是在妇女与严重的EA。这些研究结果提供的证据表明，皮质运动预测可能是一个关键组成部分，改变了神经回路的虐待史的成年人，并可能与精神病理学中的应激神经调质的改变。
Adverse caregiving during development can produce long-lasting changes to neural, endocrine, and behavioral responses to stress, and is strongly related to elevated risk of adult psychopathology. While prior experience of adversity is associated with altered sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis activity, the underlying neural pathways are not completely understood. In a double-blind crossover study, we used diffusion tensor imaging (DTI) to examine whether variation in white matter structure predicts differences in HPA-SNS interactions as a function of early adversity. Participants included 74 women who exhibited a wide range of depression severity and/or childhood emotional abuse (EA). Participants attended two experimental sessions during which they were administered 20 mg cortisol (CORT) or placebo and after 90 min, viewed emotionally laden pictures while undergoing MRI scanning. Immediately after emotional picture-viewing, we collected salivary alpha-amylase (sAA) to index SNS activation. We tested whether EA moderated the relation between fractional anisotropy (FA), a measure of white matter fiber structure, and sAA. In the placebo condition, for participants with minimal history of EA, higher FA in corticomotor projections was negatively correlated with sAA, whereas in participants with severe EA, the correlation was trending in the opposite direction. Following CORT administration, FA and sAA were not related, suggesting that SNS tone during acute cortisol elevation may depend on neural pathways other than corticomotor projections. The results suggest that at baseline—though not during cortisol elevation—increased FA in these tracts is associated with lower levels of SNS activity in women with minimal EA, but not in women with severe EA. These findings provide evidence that corticomotor projections may be a key component of altered neural circuitry in adults with history of maltreatment, and may be related to alterations in stress neuromodulators in psychopathology.
登录
查看更多内容
影响因子：
4.8
作者：
Abercrombie HC;Jahn AL;Davidson RJ;Kern S;Kirschbaum C;Halverson J
通讯作者：
Halverson J
影响因子：
3.5
作者：
Drury SS;Sánchez MM;Gonzalez A
通讯作者：
Gonzalez A
DOI：
10.1146/annurev-clinpsy-032210-104535
发表时间：
2011-01-01
影响因子：
18.4
作者：
Dimidjian, Sona;Barrera, Manuel, Jr.;Lewinsohn, Peter M.
通讯作者：
Lewinsohn, Peter M.
DOI：
10.1073/pnas.1605044113
发表时间：
2016-08-30
影响因子：
11.1
作者：
Dum, Richard P.;Levinthal, David J.;Strick, Peter L.
通讯作者：
Strick, Peter L.
影响因子：
3.3
作者：
Ellis, BJ;Essex, MJ;Boyce, WT
通讯作者：
Boyce, WT