Insular Cortical Thickness in Patients With Somatoform Pain Disorder: Are There Associations With Symptom Severity and Childhood Trauma?
Insular Cortical Thickness in Patients With Somatoform Pain Disorder: Are There Associations With Symptom Severity and Childhood Trauma?
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DOI：
10.3389/fpsyt.2020.497100
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发表时间：
2020
影响因子：
4.7
通讯作者：
Erim Y
中科院分区：
文献类型：
--
作者：
Meyer E;Morawa E;Nacak Y;Rösch J;Doerfler A;Forster C;Erim Y
研究表明，在岛皮质厚度的显着改变，躯体形式疼痛障碍（SPD）患者。此外，已观察到儿童期虐待与岛叶皮质形态学改变之间的关联。由于SPD患者经常报告不良的童年经历，我们感兴趣的是SPD患者在儿童期遭受虐待和岛叶皮质厚度之间的相互关系。15名SPD成人患者（ICD-10 F 45.40/41，DSM代码307.80）和13名健康成人对照进行了T1加权MR脑成像。在基于体素的形态测定（VBM）分析中，我们使用Student双样本t检验比较了患者和对照之间的全脑皮质厚度（p <0.05）。然后，我们进行了二次分析，以检测两组之间岛叶皮质中皮质厚度水平的差异。为了进一步分析岛叶皮质厚度的差异，我们使用性别、年龄、抑郁症状[患者健康问卷（PHQ）-9]和全脑皮质厚度作为滋扰协变量。随后，我们探讨了两组中岛叶皮质厚度、症状严重程度（PHQ-15）和过去儿童期虐待经历（CTQ）之间的关系。患者在右侧Brodmann区（BA）13（岛叶皮质前部）的一个亚区显示岛叶皮质厚度减少，而两组之间的全脑皮质厚度没有差异。任何协变量都没有减少右侧BA 13的已确定岛叶亚区的组间差异。这意味着，在确定的岛叶分区皮质厚度的减少可能是由于一个特定的组效应。效应量表明，患者组经历了更多的儿童虐待比对照组。尽管如此，岛叶皮质厚度与症状严重程度和儿童期虐待在总集体的显着相关性不能证明为一组患者。我们的数据表明，在确定的岛状亚区的权利BA 13的改变与躯体形式的疼痛，独立于性别，年龄，或符合抑郁水平。为了确定SPD患者的岛叶皮质厚度和儿童期虐待经历之间的显著相关性，强烈建议在较大样本范围内进行调查。
Studies show significant alterations in insular cortical thickness in patients with somatoform pain disorder (SPD). Additionally, associations between childhood maltreatment and morphometric alterations in insular cortex have been observed. Since patients with SPD often report about adverse childhood experiences, we were interested in the interrelationship of exposure to childhood maltreatment and insular cortical thickness in patients with SPD. Fifteen adult patients with SPD (ICD-10 F 45.40/41, DSM-Code 307.80) and thirteen healthy adult controls underwent T1-weighted MR brain imaging. In the voxel-based morphometry (VBM) analysis we compared whole brain cortical thickness between patients and controls using a Student’s two-sampled t-test (p < .05). Then we performed a secondary analysis to detect differences in cortical thickness levels in the insular cortex between both groups. For further analysis of differences in insular cortical thickness we used gender, age, depressive symptoms [Patient Health Questionnaire (PHQ)-9], and whole brain cortical thickness as nuisance covariates. Subsequently we explored associations between insular cortical thickness, symptom severity (PHQ-15) and past experiences of childhood maltreatment (CTQ) in both groups. Patients showed reduced insular cortical thickness in a subregion of right Brodmann area (BA) 13 (anterior part of the insular cortex), whereas whole brain cortical thickness did not differ between groups. The between-group difference in the identified insular subregion of right BA 13 was not diminished by any of the covariates. This implies that the reduction in cortical thickness in the identified insular subregion might be due to a specific group effect. The effect sizes indicate that the group of patients experienced more childhood maltreatment than the control group. Nonetheless, significant correlations of insular cortical thickness with symptom severity and childhood maltreatment in the total collective could not be demonstrated for the group of patients. Our data suggest that alterations in the identified insular subregion of right BA 13 are associated with somatoform pain, independent of gender, age, or coincident depression levels. To identify significant associations of insular cortical thickness and experiences of childhood maltreatment in patients with SPD investigations within larger samples are highly recommended.
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影响因子：
--
作者：
Edmiston, Erin E.;Wang, Fei;Mazure, Carolyn M.;Guiney, Joanne;Sinha, Rajita;Mayes, Linda C.;Blumberg, Hilary P.
通讯作者：
Blumberg, Hilary P.
影响因子：
11
作者：
Baumeister D;Akhtar R;Ciufolini S;Pariante CM;Mondelli V
通讯作者：
Mondelli V
控制情感障碍时，纤维肌痛和年龄匹配的健康受试者之间的灰质体积没有一致的差异。
影响因子：
7.4
作者：
Hsu MC;Harris RE;Sundgren PC;Welsh RC;Fernandes CR;Clauw DJ;Williams DA
通讯作者：
Williams DA
早期压力作为酒精和药物依赖性的预测因素。
影响因子：
3.4
作者：
Enoch, Mary-Anne
通讯作者：
Enoch, Mary-Anne
影响因子：
4.8
作者：
Bernstein, DP;Stein, JA;Zule, W
通讯作者：
Zule, W