Lacticaseibacillus rhamnosus Probio-M9 extends the lifespan of Caenorhabditis elegans.
Lacticaseibacillus rhamnosus Probio-M9 extends the lifespan of Caenorhabditis elegans.
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鼠李糖乳杆菌 Probio-M9 延长秀丽隐杆线虫的寿命
DOI：
10.1038/s42003-022-04031-2
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发表时间：
2022-10-27
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
益生菌的特征是可用于维持宿主肠道植物群的平衡并赋予健康效应，但很少有研究关注其延缓宿主衰老的潜力。在这里，我们证明了一种健康的母乳益生菌，即鼠李糖乳酸杆菌Probio-M9（Probio-M9），可以增强模式生物秀丽隐杆线虫的运动能力，减缓肌肉功能的下降。活益生菌M9显著延长了C. elegansin的饮食限制独立的方式。通过筛选各种衰老相关的C.在线虫中，我们发现Probio-M9通过p38级联和daf-2信号通路延长寿命，不依赖于ondaf-16，但依赖于skn-1。Probio-M9通过激活线粒体未折叠蛋白反应来保护和修复受损的线粒体。细菌代谢产物中氨基酸、鞘脂、半乳糖和脂肪酸的显著增加可能与延长C.优雅的我们发现，益生菌M9作为膳食补充剂有可能延缓衰老。elegansand还为进一步分析益生菌在改善宿主健康和延缓与年龄相关的慢性疾病的发生方面提供了新的方法和见解。
Probiotics have been characterized as useful for maintaining the balance of host gut flora and conferring health effects, but few studies have focused on their potential for delaying aging in the host. Here we show thatLacticaseibacillus rhamnosusProbio-M9 (Probio-M9), a healthy breast milk probiotic, enhances the locomotor ability and slows the decline in muscle function of the model organismCaenorhabditis elegans. Live Probio-M9 significantly extends the lifespan ofC. elegansin a dietary restriction-independent manner. By screening various aging-related mutants ofC. elegans, we find that Probio-M9 extends lifespan via p38 cascade anddaf-2signaling pathways, independent ondaf-16but dependent onskn-1. Probio-M9 protects and repairs damaged mitochondria by activating mitochondrial unfolded protein response. The significant increase of amino acids, sphingolipid, galactose and fatty acids in bacterial metabolites might be involved in extending the lifespan ofC. elegans. We reveal that Probio-M9 as a dietary supplementation had the potential to delay aging inC. elegansand also provide new methods and insights for further analyzing probiotics in improving host health and delaying the occurrence of age-related chronic diseases.
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影响因子：
3.7
作者：
Grompone G;Martorell P;Llopis S;González N;Genovés S;Mulet AP;Fernández-Calero T;Tiscornia I;Bollati-Fogolín M;Chambaud I;Foligné B;Montserrat A;Ramón D
通讯作者：
Ramón D
影响因子：
3.7
作者：
Chan JP;Brown J;Hark B;Nolan A;Servello D;Hrobuchak H;Staab TA
通讯作者：
Staab TA
影响因子：
5.4
作者：
Nguyen TP;Clarke CF
通讯作者：
Clarke CF
影响因子：
3.8
作者：
Abada, Emad Abd-elmoniem;Sung, Hyun;Ahnn, Joohong
通讯作者：
Ahnn, Joohong
影响因子：
2.9
作者：
Edwards C;Canfield J;Copes N;Brito A;Rehan M;Lipps D;Brunquell J;Westerheide SD;Bradshaw PC
通讯作者：
Bradshaw PC