Comparative genomics of the Rab protein family in Apicomplexan parasites.
Comparative genomics of the Rab protein family in Apicomplexan parasites.
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DOI：
10.1016/j.micinf.2008.01.017
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发表时间：
2008-04
影响因子：
5.8
通讯作者：
Pain A
中科院分区：
文献类型：
--
作者：
Langsley G;van Noort V;Carret C;Meissner M;de Villiers EP;Bishop R;Pain A
Rab基因编码ras超家族中的一个小gtp结合蛋白亚组，在分泌和内吞途径中调节转运囊泡的靶向和融合。这些基因在原生动物顶复合体门中特别有趣，因为已经描述了疟原虫的Rab gtpase家族，并且顶复合体中大多数假定的分泌途径蛋白具有常规预测的信号肽。此外，现在已经在大量分泌的疟原虫蛋白中确定了肽基序，这些蛋白可将其靶向红细胞胞浆、顶质体、食物液泡和毛雷尔氏裂孔；相比之下，将蛋白质导向分泌细胞器（红体、微球和微球）的基序尚未被定义。这些蛋白质被运送到目的地的囊泡的性质仍然未知，并且在顶复合体中无法看到与其他真核生物典型的内质网和反式高尔基堆积相当的形态结构。由于Rab gtpase调节所有真核生物的囊泡运输，并且细胞内寄生虫的这种运输可以调节营养物质和药物的进口以及抗原、宿主细胞调节蛋白和乳酸的出口，我们在这里比较和对比了顶复合体的Rab家族。
Rab genes encode a subgroup of small GTP-binding proteins within the ras super-family that regulate targeting and fusion of transport vesicles within the secretory and endocytic pathways. These genes are of particular interest in the protozoan phylum Apicomplexa, since a family of Rab GTPases has been described for Plasmodium and most putative secretory pathway proteins in Apicomplexa have conventional predicted signal peptides. Moreover, peptide motifs have now been identified within a large number of secreted Plasmodium proteins that direct their targeting to the red blood cell cytosol, the apicoplast, the food vacuole and Maurer's clefs; in contrast, motifs that direct proteins to secretory organelles (rhoptries, micronemes and microspheres) have yet to be defined. The nature of the vesicle in which these proteins are transported to their destinations remains unknown and morphological structures equivalent to the endoplasmic reticulum and trans-Golgi stacks typical of other eukaryotes cannot be visualised in Apicomplexa. Since Rab GTPases regulate vesicular traffic in all eukaryotes, and this traffic in intracellular parasites could regulate import of nutrient and drugs and export of antigens, host cell modulatory proteins and lactate we compare and contrast here the Rab families of Apicomplexa.
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影响因子：
14.9
作者：
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作者：
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