Diffusion-weighted MR imaging of fetal lung maturation in sheep: effect of prenatal cortisone administration on ADC values
Diffusion-weighted MR imaging of fetal lung maturation in sheep: effect of prenatal cortisone administration on ADC values
复制标题
绵羊胎肺成熟度的弥散加权 MR 成像：产前可的松给药对 ADC 值的影响
DOI：
10.1007/s00330-013-2780-7
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发表时间：
2013
影响因子：
5.9
通讯作者：
Wedegaertner U
中科院分区：
文献类型：
--
作者：
Much CC;Schoennagel BP;Yamamura J;Buchert R;Kooijman H;Schätzle AK;Adam G;Wedegaertner U
目的应用扩散加权成像（DWI）技术研究胎羊应用可的松后胎肺弥散特性的变化。四只动物在基线成像前接受可的松注射。7只动物作为对照。由两名独立的读片员在DWI上测量胎儿肺的表观扩散系数（ADC）。Pearson检验用于ADC与胎龄的相关性。进行At检验，以比较组内和组间基线和随访图像ADC值的差异。评价者间的可靠性计算。结果在可的松组，ADC值增加约10%之间的基线和随访图像（P= 0.039）。与对照组相比，基线图像的ADC值没有差异;而在随访成像中，可的松组的ADC值显著较高（P= 0.024）。肺ADC值与胎龄无关（P= 0.970）。评分者间信度较高（0.970，P = 0.000）.结论在本实验模型中，MR-DWI可以检测到皮质激素诱导的胎儿肺弥散特性的变化。要点·产前经常使用皮质类固醇，以防止出生时胎儿肺不成熟·DWI可以检测到皮质类固醇给药后胎儿肺的变化·最早可以在治疗后5天检测到变化·胎儿MRI可能提供一种非侵入性的监测肺成熟的方法
ObjectiveTo assess changes in diffusion properties in the fetal lung after cortisone administration with diffusion-weighted imaging (DWI) in fetal sheep.MethodsDWI was performed on 11 pregnant sheep with singleton pregnancies on a 1.5-T MRI scanner. Four animals received cortisone injections before baseline imaging. Seven animals served as controls. Apparent diffusion coefficient (ADC) was measured on DWI in the fetal lungs by two independent readers. The Pearson test was used to correlate ADC and gestational age. At-test was performed to compare differences in ADC values at the baseline and follow-up images within and between groups. Inter-rater reliability was calculated.ResultsIn the cortisone group, ADC values increased about 10 % between the baseline and follow-up images (P= 0.039). Comparing the cortisone and control groups, ADC values of the baseline images did not differ; whereas in the follow-up imaging, ADC values were significantly higher in the cortisone group (P= 0.024). Lung ADC values did not correlate with gestational age (P= 0.970). Inter-rater reliability was high (0.970,P= 0.000).ConclusionIn this experimental model, MR-DWI can detect cortisone-induced changes in diffusion properties of the fetal lung.Key Points•Corticosteroids are frequently administered antenatally to prevent fetal lung immaturity at birth•DWI can detect changes in the fetal lung after corticosteroid administration•Changes can be detected as early as 5 days after treatment•Fetal MRI may offer a non-invasive method of monitoring lung maturation
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