Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep.
Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep.
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早产羊重复产前糖皮质激素治疗后的肺形态测定。
DOI：
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发表时间：
2001
影响因子：
24.7
通讯作者：
P. Sly
中科院分区：
文献类型：
--
作者：
K. Willet;A. Jobe;M. Ikegami;Jana Kovar;P. Sly
产前糖皮质激素被认为在治疗开始后 7 天以上分娩时效果较差；因此，经常开设重复课程。我们在胎羊单次或重复产前注射糖皮质激素后检查了肺结构。怀孕母羊通过母体或胎儿注射，以 7 天的间隔接受单次或重复剂量的 0.5 mg/kg 倍他米松，从 D104 或 D114 开始，在妊娠 D125、D135 或 D146 分娩（妊娠期 = 150 天）。与单次注射相比，重复注射后肺部结构的变化更加明显。从 D104 开始（D125 分娩）重复进行胎儿或母体注射会导致类似的结构变化：肺泡体积增加 50% 至 80%，肺泡数值密度减少 30% 至 40%，胸膜和小叶间隔体积减少多达 70%。在 D114 开始重复母体注射后，在 D135 分娩的动物中也观察到类似的变化。当分娩延迟至 D146 时，对照动物和重复倍他米松动物之间没有结构差异，表明倍他米松诱导的结构变化是可逆的。
Antenatal glucocorticoids are thought to be less effective when delivery occurs more than 7 d after initiation of treatment; therefore, repeat courses are often administered. We examined lung structure after single or repetitive antenatal glucocorticoid injections in fetal sheep. Pregnant ewes received single or repetitive doses of 0.5 mg/kg betamethasone at 7-d intervals by maternal or fetal injection, beginning at D104 or D114 with delivery at D125, D135, or D146 gestation (term = 150 d). Changes in lung structure were more pronounced after repetitive versus single injections. Repetitive fetal or maternal injections beginning at D104 (delivery at D125) resulted in comparable structural changes: alveolar volume increased by 50 to 80%, alveolar numerical density decreased by 30 to 40%, and pleural and interlobular septal volumes decreased by as much as 70%. Similar changes were seen in animals delivered at D135 after repetitive maternal injections beginning at D114. There were no structural differences between control and repetitive betamethasone animals when delivery was delayed until D146, indicating that betamethasone induced structural changes were reversible.
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DOI：
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发表时间：
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影响因子：
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