Roles of Porphyromonas gingivalis and its virulence factors in periodontitis.
Roles of Porphyromonas gingivalis and its virulence factors in periodontitis.
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DOI：
10.1016/bs.apcsb.2019.12.001
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发表时间：
2020
影响因子：
--
通讯作者：
Liang S
中科院分区：
文献类型：
--
作者：
Xu W;Zhou W;Wang H;Liang S
牙周炎是一种感染驱动的炎症性疾病，其特征是牙龈炎症和骨丢失。牙周炎与各种系统性疾病有关，包括心血管、呼吸系统、肌肉骨骼和生殖系统相关的异常。目前的理论认为牙周炎的发病机制是口腔微生物生态失调，其中牙龈卟啉单胞菌通过破坏宿主免疫稳态而起关键作用。脂多糖、蛋白酶、菌毛和一些其他毒力因子是牙龈卟啉单胞菌利用的策略之一，以促进细菌定殖并促进周围微生物群落的生长。毒力因子促进牙龈卟啉单胞菌与其他细菌的共聚集和牙体生物膜的形成。这些毒力因子还调节多种宿主免疫组分并破坏免疫应答以逃避细菌清除或诱导炎性环境。在本章中，我们的重点是讨论牙周病原体，特别是牙龈卟啉单胞菌的毒力因子，以及它们在调节牙周炎进展过程中的免疫反应中的作用。
Periodontitis is an infection-driven inflammatory disease, which is characterized by gingival inflammation and bone loss. Periodontitis is associated with various systemic diseases, including cardiovascular, respiratory, musculoskeletal, and reproductive system related abnormalities. Recent theory attributes the pathogenesis of periodontitis to oral microbial dysbiosis, in which Porphyromonas gingivalis acts as a critical agent by disrupting host immune homeostasis. Lipopolysaccharide, proteases, fimbriae, and some other virulence factors are among the strategies exploited by P. gingivalis to promote the bacterial colonization and facilitate the outgrowth of the surrounding microbial community. Virulence factors promote the coaggregation of P. gingivalis with other bacteria and the formation of dental biofilm. These virulence factors also modulate a variety of host immune components and subvert the immune response to evade bacterial clearance or induce an inflammatory environment. In this chapter, our focus is to discuss the virulence factors of periodontal pathogens, especially P. gingivalis, and their roles in regulating immune responses during periodontitis progression.
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DOI：
10.4049/jimmunol.1202339
发表时间：
2012-12-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Abe T;Hosur KB;Hajishengallis E;Reis ES;Ricklin D;Lambris JD;Hajishengallis G
通讯作者：
Hajishengallis G
影响因子：
3.1
作者：
Baker, PJ;Dixon, M;Roopenian, DC
通讯作者：
Roopenian, DC
影响因子：
4.2
作者：
Bao K;Belibasakis GN;Thurnheer T;Aduse-Opoku J;Curtis MA;Bostanci N
通讯作者：
Bostanci N
影响因子：
3
作者：
BAKER, PJ;EVANS, RT;ROOPENIAN, DC
通讯作者：
ROOPENIAN, DC
影响因子：
18.6
作者：
Amano, Atsuo
通讯作者：
Amano, Atsuo