Activation of brainstem neurons by underwater diving in the rat.
Activation of brainstem neurons by underwater diving in the rat.
复制标题
通过大鼠水下潜水激活脑干神经元。
DOI：
10.3389/fphys.2012.00111
复制
发表时间：
2012
影响因子：
4
通讯作者：
Juric R
中科院分区：
文献类型：
--
作者：
Panneton WM;Gan Q;Le J;Livergood RS;Clerc P;Juric R
哺乳动物的潜水反应是对水下浸没的强大自主调节，极大地影响心率、动脉血压和通气。心动过缓由副交感神经系统介导，动脉血压通过交感神经系统介导，还有其他回路介导呼吸变化。在本研究中，我们调查的心肺反应和脑干神经元激活自愿潜水训练的大鼠，并比较它们的控制和游泳动物没有潜水。我们发现，由潜水引起的心动过缓和动脉血压升高与游泳引起的有显着不同。在对脑干切片进行Fos蛋白免疫组织化学处理后计算神经元活化。在尾加压区、延髓背角、孤束核（NTS）亚核、中缝苍白核（RPa）、延髓头端腹外侧区、A5区、蓝斑核、Köliker-Ehrman区、臂旁核的外侧亚核和上级外侧亚核中计数标记神经元。所有这些领域表现出显着增加Fos标记时，自愿潜水大鼠的数据相比，对照组大鼠和所有，但连合亚核的NTS，A5区，和RPa游泳大鼠有显着差异。这些数据为更精确的实验提供了基础，以确定这些核在驱动潜水反应的反射回路中的作用。
The mammalian diving response is a powerful autonomic adjustment to underwater submersion greatly affecting heart rate, arterial blood pressure, and ventilation. The bradycardia is mediated by the parasympathetic nervous system, arterial blood pressure is mediated via the sympathetic system and still other circuits mediate the respiratory changes. In the present study we investigate the cardiorespiratory responses and the brainstem neurons activated by voluntary diving of trained rats, and, compare them to control and swimming animals which did not dive. We show that the bradycardia and increase in arterial blood pressure induced by diving were significantly different than that induced by swimming. Neuronal activation was calculated after immunohistochemical processing of brainstem sections for Fos protein. Labeled neurons were counted in the caudal pressor area, the medullary dorsal horn, subnuclei of the nucleus tractus solitarii (NTS), the nucleus raphe pallidus (RPa), the rostroventrolateral medulla, the A5 area, the nucleus locus coeruleus, the Kölliker–Fuse area, and the external lateral and superior lateral subnuclei of the parabrachial nucleus. All these areas showed significant increases in Fos labeling when data from voluntary diving rats were compared to control rats and all but the commissural subnucleus of the NTS, A5 area, and RPa were significantly different from swimming rats. These data provide a substrate for more precise experiments to determine the role of these nuclei in the reflex circuits driving the diving response.
登录
查看更多内容
影响因子：
2.9
作者：
Dutschmann, M;Guthmann, A;Herbert, H
通讯作者：
Herbert, H
影响因子：
4
作者：
Dampney, RAL;Polson, JW;Horiuchi, J
通讯作者：
Horiuchi, J
DOI：
10.1523/jneurosci.1299-11.2011
发表时间：
2011-07-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cavanaugh DJ;Chesler AT;Bráz JM;Shah NM;Julius D;Basbaum AI
通讯作者：
Basbaum AI
影响因子：
2.9
作者：
BULLITT, E;LEE, CL;WILLCOCKSON, H
通讯作者：
WILLCOCKSON, H
影响因子：
2.9
作者：
Blessing, WW;Yu, YH;Nalivaiko, E
通讯作者：
Nalivaiko, E