Central angiotensin I increases swallowing activity and oxytocin release in the near-term ovine fetus.
Central angiotensin I increases swallowing activity and oxytocin release in the near-term ovine fetus.
复制标题
中枢血管紧张素 I 增加近期绵羊胎儿的吞咽活动和催产素释放
DOI：
10.1159/000332736
复制
发表时间：
2012
影响因子：
4.1
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Shi L;Mao C;Zeng F;Zhang L;Xu Z
脑组织中的肾素-血管紧张素系统（RAS）在水矿平衡和神经内分泌平衡中起着重要作用。虽然以前的研究表明，外源性血管紧张素（Ang）II增加dipsogenic和加压素的反应，在近足月胎儿，胎儿内源性脑RAS的功能发育的体液平衡的调节知之甚少。为了确定中央血管紧张素转换酶（ACE）在子宫内的功能发展，我们研究了皮层电活动（ECoG），吞咽活动，催产素（OT）的释放，和c-fos表达在脑室内血管紧张素I管理在近期胎羊。Ang I不改变胎儿低电压（LV）和高电压（HV）ECoG的时间分布，但增加LV ECoG期间胎儿吞咽活动（1.0 ± 0.1 ~ 3.5 ± 0.4次/min）。此外，血管紧张素I引起的c-fos-免疫反应性的增加，在假定的dippogenic中心，包括视上和室旁核的下丘脑，伴随着胎儿血浆OT水平的增加。c-fos在下丘脑OT神经元表达。卡托普利可抑制Ang I介导的胎儿吞咽和血浆OT增加。这些结果表明，在妊娠的最后三个月，胎脑ACE系统的功能发展，它在RAS介导的致渴反应和OT释放的体液平衡的调节中起着重要作用。
The brain renin-angiotensin system (RAS) plays an important role in hydromineral and neuroendocrine balance. Although previous studies showed that exogenous angiotensin (Ang) II increased dipsogenic and vasopressin responses in near-term fetuses, little is known about the functional development of fetal endogenous brain RAS in the regulation of body fluid homeostasis. To determine the functional development of the central angiotensin-converting enzyme (ACE) in utero, we investigated the electrocortical (ECoG) activity, swallowing activity, oxytocin (OT) release, and c-fos expression in response to intracerebroventricular Ang I administration in the near-term fetal lamb. Ang I did not change fetal low-voltage (LV) and high-voltage (HV) ECoG temporal distributions, but increased fetal swallowing activity during LV ECoG (1.0 ± 0.1 to 3.5 ± 0.4 swallows/min). Additionally, Ang I evoked an increase in c-fos-immunoreactivity in putative dipsogenic centers, including the supraoptic and paraventricular nuclei of the hypothalamus, accompanied by an increase in fetal plasma OT levels. The expression of c-fos was demonstrated in OT neurons in the hypothalamus. The Ang I-mediated increase in fetal swallowing and plasma OT was inhibited by captopril. These results demonstrate the functional development of the fetal brain ACE system in the last trimester of gestation, which plays an important role in the RAS-mediated dipsogenic response and OT release in the regulation of body fluid homeostasis.
登录
查看更多内容
影响因子：
2.1
作者：
FERGUSON, AV;WALL, KM
通讯作者：
WALL, KM
DOI：
10.1016/j.devbrainres.2004.02.007
发表时间：
2004-05-19
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Hu, F;Morrissey, P;Xu, ZC
通讯作者：
Xu, ZC
影响因子：
19.6
作者：
Butkus, A;Albiston, A;Wintour, EM
通讯作者：
Wintour, EM
DOI：
10.1016/s0002-9378(97)70024-3
发表时间：
1997-11-01
影响因子：
9.8
作者：
Nijland, MJM;Chao, CR;Ross, MG
通讯作者：
Ross, MG
影响因子：
56.9
作者：
SIMPSON, JB;ROUTTENBERG, A
通讯作者：
ROUTTENBERG, A