Metalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet Aggregation from Snake Venoms: Definition and Nomenclature of Interaction Sites.
Metalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet Aggregation from Snake Venoms: Definition and Nomenclature of Interaction Sites.
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DOI：
10.3390/toxins8100284
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发表时间：
2016-09-29
期刊：
影响因子：
4.2
通讯作者：
Koh CY
中科院分区：
文献类型：
--
作者：
Kini RM;Koh CY
蛇毒金属蛋白酶除了参与猎物的消化外，还通过切割特定的蛋白质来影响各种生理功能。它们通过激活凝血因子的酶原和整合素或受体的前体来显示其活性。根据蛋白酶的结构功能关系和作用机制，对蛋白酶的功能位点进行了分类和命名。这些金属蛋白酶可用作研究工具，并可用于诊断和治疗各种血栓形成和止血病症。它们还有助于我们了解凝血、血小板聚集和基质生物学中特定因子活化的分子细节。本文综述了金属蛋白酶对凝血、纤溶和血小板聚集的影响。
Snake venom metalloproteases, in addition to their contribution to the digestion of the prey, affect various physiological functions by cleaving specific proteins. They exhibit their activities through activation of zymogens of coagulation factors, and precursors of integrins or receptors. Based on their structure–function relationships and mechanism of action, we have defined classification and nomenclature of functional sites of proteases. These metalloproteases are useful as research tools and in diagnosis and treatment of various thrombotic and hemostatic conditions. They also contribute to our understanding of molecular details in the activation of specific factors involved in coagulation, platelet aggregation and matrix biology. This review provides a ready reference for metalloproteases that interfere in blood coagulation, fibrinolysis and platelet aggregation.
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