Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease.
Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease.
复制标题
脂肪组织功能障碍及其在非酒精性脂肪性肝病发病机制中的作用研究进展
作者：
Wang X;Rao H;Liu F;Wei L;Li H;Wu C
肥胖是一个严重的持续健康问题，显著增加非酒精性脂肪肝（NAFLD）的发病率。肥胖期间，脂肪组织功能障碍明显，其特征是脂肪沉积增加（肥胖）和慢性低度炎症。后者被认为严重促进了NAFLD的发展和进展，其晚期形式的非酒精性脂肪性肝炎（NASH）被认为是终末期肝病最常见的原因之一。本文就肥胖相关脂肪功能障碍及其在肝脂肪变性、炎症和肝纤维化发病机制中的作用作一综述。更好地理解肥胖下脂肪组织和肝脏之间的串扰对于开发新的和改进的预防和/或治疗方法来管理NAFLD是必不可少的。
Obesity is a serious ongoing health problem that significantly increases the incidence of nonalcoholic fatty liver disease (NAFLD). During obesity, adipose tissue dysfunction is obvious and characterized by increased fat deposition (adiposity) and chronic low-grade inflammation. The latter has been implicated to critically promote the development and progression of NAFLD, whose advanced form non-alcoholic steatohepatitis (NASH) is considered one of the most common causes of terminal liver diseases. This review summarizes the current knowledge on obesity-related adipose dysfunction and its roles in the pathogenesis of hepatic steatosis and inflammation, as well as liver fibrosis. A better understanding of the crosstalk between adipose tissue and liver under obesity is essential for the development of new and improved preventive and/or therapeutic approaches for managing NAFLD.
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影响因子：
4.3
作者：
Dyar KA;Eckel-Mahan KL
通讯作者：
Eckel-Mahan KL
影响因子：
158.5
作者：
Cuchel, Marina;Bloedon, LeAnne T.;Rader, Daniel J.
通讯作者：
Rader, Daniel J.
影响因子：
5
作者：
DeOliveira, Caroline Candida;Caria, Cintia Rabelo E. Paiva;Gambero, Alessandra
通讯作者：
Gambero, Alessandra
影响因子：
16.6
作者：
Blondin DP;Tingelstad HC;Noll C;Frisch F;Phoenix S;Guérin B;Turcotte ÉE;Richard D;Haman F;Carpentier AC
通讯作者：
Carpentier AC
影响因子：
7.8
作者：
Alchera, Elisa;Rolla, Simona;Carini, Rita
通讯作者：
Carini, Rita