The mediating role of socioeconomic status on the relationship between pregnancy history and later-life cognition.
The mediating role of socioeconomic status on the relationship between pregnancy history and later-life cognition.
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DOI：
10.1080/13697137.2022.2129004
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发表时间：
2022-12
期刊：
影响因子：
2.8
通讯作者：
Panizzon, M. S.
中科院分区：
文献类型：
--
作者：
Giudicessi, A. J.;Saelzler, U. G.;Shadyab, A. H.;Posis, A. I. B.;Sundermann, E. E.;Banks, S. J.;Panizzon, M. S.
关键词：
怀孕与晚年认知之间的联系还没有被很好地理解。我们调查了绝经后妇女样本中足月妊娠和不完全妊娠是否与认知有关，以及社会经济地位(SES)因素是否中介了这些关系。对1,016名来自国家健康与营养调查(NHANES)的认知正常妇女进行了检查。认知测试包括数字符号替代测试(DSST)、动物流利性(AF)、建立阿尔茨海默病登记处(CERAD)的联合会、单词学习(CERAD-WL)和CERAD延迟回忆(CERAD-DR)任务。分析考察了足月妊娠和不完全怀孕的数量与认知表现之间的关系，以及教育和收入-贫困比率(PIR)的中介作用。足月妊娠数越多，在DST(β=−0.09，95%可信区间[CI]−0.12至−0.06)、房颤(β=−0.03，95%CI−0.07至0.00)和CERAD-DR(β=−0.04，95%CI−0.08至−0.01)上表现较差。更多的不完全妊娠与更好的CERAD-DR表现相关(β=0.07，95%CI 0.01~0.13)，28%(95%CI：0.17~0.42)的足月妊娠与DST的关联是由PIR中介的。足月妊娠次数越多，认知表现越差，而不完全妊娠次数越多，认知表现越好。结果表明，在研究妊娠与认知之间的关系时，有必要考虑SES因素。
The association of pregnancy with later-life cognition is not well understood. We examined whether full-term and incomplete pregnancies were associated with cognition in a sample of post-menopausal women, and whether socioeconomic status (SES) factors mediated these relationships. 1,016 cognitively normal women from National Health and Nutrition Examination Survey (NHANES) were examined. Cognitive measures included Digit Symbol Substitution Test (DSST), Animal Fluency (AF), Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Word Learning (CERAD-WL) and CERAD Delayed Recall (CERAD-DR) tasks. Analyses examined the relationship between number of term and incomplete pregnancies with cognitive performance, as well as the mediating effects of education and income-poverty ratio (PIR). A greater number of term pregnancies was associated with worse performance on DSST (β = −0.09, 95% confidence interval [CI] −0.12 to −0.06), AF (β = −0.03, 95% CI −0.07 to 0.00) and CERAD-DR (β = −0.04, 95% CI −0.08 to −0.01). More incomplete pregnancies were associated with better CERAD-DR performance (β = 0.07, 95% CI 0.01 to 0.13), 28% (95% CI: 0.17–0.42) of the association of term pregnancies with DSST was mediated by PIR. Higher number of term pregnancies was associated with worse cognitive performance, whereas higher number of incomplete pregnancies was associated with better cognitive performance. Results indicate the necessity to consider SES factors when studying the relationship between pregnancy and cognition.
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黄体酮和人类认知。
DOI：
10.1080/13697137.2018.1476484
发表时间：
2018-08
期刊：
Climacteric : the journal of the International Menopause Society
影响因子：
--
作者：
Henderson VW
通讯作者：
Henderson VW
影响因子：
3.8
作者：
Chavez-MacGregor, Mariana;van Gils, Carla H.;Peeters, Petra H. M.
通讯作者：
Peeters, Petra H. M.
影响因子：
14
作者：
通讯作者：
--
影响因子：
7.2
作者：
Harville，Emily W.;Guralnik，Jack;Bazzano，Lydia A.
通讯作者：
Bazzano，Lydia A.
影响因子：
7
作者：
Imai, Kosuke;Keele, Luke;Tingley, Dustin
通讯作者：
Tingley, Dustin