Adipokine hormones and hand osteoarthritis: radiographic severity and pain.
Adipokine hormones and hand osteoarthritis: radiographic severity and pain.
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DOI：
10.1371/journal.pone.0047860
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Solomon DH
中科院分区：
文献类型：
--
作者：
Massengale M;Lu B;Pan JJ;Katz JN;Solomon DH
肥胖与手骨关节炎的关系不能完全用机械负荷来解释。我们研究了脂肪因子与放射学手骨关节炎严重程度和疼痛之间的关系。在44名手骨关节炎患者（39名女性和5名男性）的初步研究中，使用线性回归模型分析血清脂肪因子浓度和手X线Kallman评分。次要分析检查了手部疼痛的相关性。该队列的女性平均年龄为63.5岁，男性为72.6岁;女性平均（标准差）Kallman评分为43.3（17.4），男性为46.2（10.8）。女性和男性的平均体重指数为30 kg/m2。平均瘦素浓度为32.2 ng/ml（女性）和18.5 ng/ml（男性）;平均总脂联素为7.9 ng/ml（女性）和5.3 ng/ml（男性）;平均瘦素为7.3 ng/ml（女性）和9.4 ng/ml（男性）。在Kallman评分和脂肪因子浓度之间没有发现关联（R2 = 0.00-0.04未校正分析，所有p值>0.22）。 次要分析显示，女性的平均视觉模拟量表疼痛为4.8（2.4），男性为6.6（0.9）。发现瘦素、BMI和冠状动脉疾病史与慢性手部疼痛的视觉模拟量表评分相关（R2 = 0.36，未校正分析，p值≤0.04）。 在这项初步研究中，我们发现脂肪因子血清浓度与手骨关节炎放射学严重程度无关;关节损伤最重要的相关因素是年龄和病程。血清瘦素浓度、体重指数和冠状动脉疾病与慢性手部OA疼痛的强度相关。
Obesity's association with hand osteoarthritis cannot be fully explained by mechanical loading. We examined the relationship between adipokines and radiographic hand osteoarthritis severity and pain. In a pilot study of 44 hand osteoarthritis patients (39 women and 5 men), serum adipokine concentrations and hand x-ray Kallman-scores were analyzed using linear regression models. Secondary analyses examined correlates of hand pain. The cohort had a mean age of 63.5 years for women and 72.6 for men; mean (standard deviation) Kallman-scores were 43.3(17.4) for women and 46.2(10.8) for men. Mean body-mass-index was 30 kg/m2 for women and men. Mean leptin concentration was 32.2 ng/ml (women) and 18.5 ng/ml (men); mean adiponectin-total was 7.9 ng/ml (women) and 5.3 ng/ml (men); mean resistin was 7.3 ng/ml (women) and 9.4 ng/ml (men). No association was found between Kallman-scores and adipokine concentrations (R2 = 0.00–0.04 unadjusted analysis, all p-values>0.22). Secondary analyses showed mean visual-analog-scale pain of 4.8(2.4) for women and 6.6(0.9) for men. Leptin, BMI, and history of coronary artery disease were found to be associated with visual-analog-scale scores for chronic hand pain (R2 = 0.36 unadjusted analysis, p-values≤0.04). In this pilot study, we found that adipokine serum concentrations were not associated with hand osteoarthritis radiographic severity; the most important correlates of joint damage were age and disease duration. Leptin serum concentration, BMI, and coronary artery disease were associated with the intensity of chronic hand OA pain.
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影响因子：
3.8
作者：
Kaplan, Robert C.;Ho, Gloria Y. F.;Anastos, Kathryn
通讯作者：
Anastos, Kathryn
影响因子：
4.2
作者：
Choe, Jung-Yoon;Bae, Jisuk;Kim, Seong-Kyu
通讯作者：
Kim, Seong-Kyu
影响因子：
27.4
作者：
Yusuf, Erlangga;Ioan-Facsinay, Andreea;Kloppenburg, Margreet
通讯作者：
Kloppenburg, Margreet
影响因子：
--
作者：
ALTMAN, R;ALARCON, G;WOLFE, F
通讯作者：
WOLFE, F
影响因子：
--
作者：
KALLMAN, DA;WIGLEY, FM;TOBIN, JD
通讯作者：
TOBIN, JD