A role for a novel centrosome cycle in asymmetric cell division.
A role for a novel centrosome cycle in asymmetric cell division.
复制标题
新型中心体周期在不对称细胞分裂中的作用。
DOI：
10.1083/jcb.200612140
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发表时间：
2007-04-09
影响因子：
7.8
通讯作者：
Peifer, Mark
中科院分区：
文献类型：
--
作者：
Rusan, Nasser M.;Peifer, Mark
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Tissue stem cells play a key role in tissue maintenance. Drosophila melanogaster central brain neuroblasts are excellent models for stem cell asymmetric division. Earlier work showed that their mitotic spindle orientation is established before spindle formation. We investigated the mechanism by which this occurs, revealing a novel centrosome cycle. In interphase, the two centrioles separate, but only one is active, retaining pericentriolar material and forming a “dominant centrosome.” This centrosome acts as a microtubule organizing center (MTOC) and remains stationary, forming one pole of the future spindle. The second centriole is inactive and moves to the opposite side of the cell before being activated as a centrosome/MTOC. This is accompanied by asymmetric localization of Polo kinase, a key centrosome regulator. Disruption of centrosomes disrupts the high fidelity of asymmetric division. We propose a two-step mechanism to ensure faithful spindle positioning: the novel centrosome cycle produces a single interphase MTOC, coarsely aligning the spindle, and spindle–cortex interactions refine this alignment.
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