The evolution of age-specific resistance to infectious disease.
The evolution of age-specific resistance to infectious disease.
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DOI：
10.1098/rspb.2022.2000
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发表时间：
2023-01-25
影响因子：
4.7
通讯作者：
Ashby, Ben
中科院分区：
文献类型：
--
作者：
Buckingham, Lydia J.;Bruns, Emily L.;Ashby, Ben
先天的、预防感染的抵抗力通常在宿主的生命阶段之间变化。在某些物种中，幼鱼比成年鱼更具抵抗力，而在另一些物种中则相反。这种变化并不总是由先前的暴露或生理限制来解释，因此有人假设可能涉及与其他生活史特征的权衡。然而，很少有人知道如何权衡各种生活史性状和阻力在不同的生命阶段影响年龄特异性阻力的演变。在这里，我们使用一个数学模型来探讨如何权衡自然死亡率，繁殖和成熟联合收割机结合，以影响在不同的生命阶段的电阻的演变。我们的研究结果表明，某些组合的权衡有实质性的影响，无论是成年人或青少年更有抵抗力，与青少年抵抗力和成年人生殖之间的权衡固有的成本比涉及成熟或死亡率的权衡（所有其他条件相同），导致一致的进化在少年阶段的低电阻，即使感染导致终身生育力降低。我们的模型演示了如何在自然界中看到的年龄结构的阻力模式之间的差异可以解释的变化所涉及的权衡和我们的研究结果表明，在这种情况下，权衡往往选择较低的阻力在青少年比成年人。
Innate, infection-preventing resistance often varies between host life stages. Juveniles are more resistant than adults in some species, whereas the opposite pattern is true in others. This variation cannot always be explained by prior exposure or physiological constraints and so it has been hypothesized that trade-offs with other life-history traits may be involved. However, little is known about how trade-offs between various life-history traits and resistance at different life stages affect the evolution of age-specific resistance. Here, we use a mathematical model to explore how trade-offs with natural mortality, reproduction and maturation combine to affect the evolution of resistance at different life stages. Our results show that certain combinations of trade-offs have substantial effects on whether adults or juveniles are more resistant, with trade-offs between juvenile resistance and adult reproduction inherently more costly than trade-offs involving maturation or mortality (all else being equal), resulting in consistent evolution of lower resistance at the juvenile stage even when infection causes a lifelong fecundity reduction. Our model demonstrates how the differences between patterns of age-structured resistance seen in nature may be explained by variation in the trade-offs involved and our results suggest conditions under which trade-offs tend to select for lower resistance in juveniles than adults.
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影响因子：
2.1
作者：
通讯作者：
--
对病毒感染和宿主生长速率的构型抵抗之间的基因型权衡。
DOI：
10.1111/evo.13623
发表时间：
2018-12
期刊：
Evolution; international journal of organic evolution
影响因子：
--
作者：
Bartlett LJ;Wilfert L;Boots M
通讯作者：
Boots M
DOI：
10.1098/rspb.2018.0844
发表时间：
2018-06-27
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Ashby B;Bruns E
通讯作者：
Bruns E
影响因子：
2.2
作者：
Armitage, Sophie A. O.;Boomsma, Jacobus J.
通讯作者：
Boomsma, Jacobus J.
影响因子：
3.1
作者：
CHAPLIN, JF;MANN, TJ
通讯作者：
MANN, TJ