The Environmental Conditions, Treatments, and Exposures Ontology (ECTO): connecting toxicology and exposure to human health and beyond.
The Environmental Conditions, Treatments, and Exposures Ontology (ECTO): connecting toxicology and exposure to human health and beyond.
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DOI：
10.1186/s13326-023-00283-x
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发表时间：
2023-02-24
影响因子：
1.9
通讯作者：
中科院分区：
文献类型：
--
作者：
Evaluating the impact of environmental exposures on organism health is a key goal of modern biomedicine and is critically important in an age of greater pollution and chemicals in our environment. Environmental health utilizes many different research methods and generates a variety of data types. However, to date, no comprehensive database represents the full spectrum of environmental health data. Due to a lack of interoperability between databases, tools for integrating these resources are needed. In this manuscript we present the Environmental Conditions, Treatments, and Exposures Ontology (ECTO), a species-agnostic ontology focused on exposure events that occur as a result of natural and experimental processes, such as diet, work, or research activities. ECTO is intended for use in harmonizing environmental health data resources to support cross-study integration and inference for mechanism discovery. ECTO is an ontology designed for describing organismal exposures such as toxicological research, environmental variables, dietary features, and patient-reported data from surveys. ECTO utilizes the base model established within the Exposure Ontology (ExO). ECTO is developed using a combination of manual curation and Dead Simple OWL Design Patterns (DOSDP), and contains over 2700 environmental exposure terms, and incorporates chemical and environmental ontologies. ECTO is an Open Biological and Biomedical Ontology (OBO) Foundry ontology that is designed for interoperability, reuse, and axiomatization with other ontologies. ECTO terms have been utilized in axioms within the Mondo Disease Ontology to represent diseases caused or influenced by environmental factors, as well as for survey encoding for the Personalized Environment and Genes Study (PEGS). We constructed ECTO to meet Open Biological and Biomedical Ontology (OBO) Foundry principles to increase translation opportunities between environmental health and other areas of biology. ECTO has a growing community of contributors consisting of toxicologists, public health epidemiologists, and health care providers to provide the necessary expertise for areas that have been identified previously as gaps. The online version contains supplementary material available at 10.1186/s13326-023-00283-x.
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影响因子：
5.6
作者：
Judson RS;Martin MT;Egeghy P;Gangwal S;Reif DM;Kothiya P;Wolf M;Cathey T;Transue T;Smith D;Vail J;Frame A;Mosher S;Hubal EAC;Richard AM
通讯作者：
Richard AM
影响因子：
1.9
作者：
Buttigieg PL;Morrison N;Smith B;Mungall CJ;Lewis SE;ENVO Consortium
通讯作者：
ENVO Consortium
影响因子：
14.9
作者：
Federhen S
通讯作者：
Federhen S
影响因子：
1.9
作者：
Buttigieg PL;Pafilis E;Lewis SE;Schildhauer MP;Walls RL;Mungall CJ
通讯作者：
Mungall CJ
影响因子：
9.8
作者：
Lozowicka, Bozena
通讯作者：
Lozowicka, Bozena