A composite score for executive functioning, validated in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment.
A composite score for executive functioning, validated in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment.
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DOI：
10.1007/s11682-012-9176-1
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发表时间：
2012-12
影响因子：
3.2
通讯作者：
Crane, Paul K.
中科院分区：
文献类型：
--
作者：
Gibbons, Laura E.;Carle, Adam C.;Mackin, R. Scott;Harvey, Danielle;Mukherjee, Shubhabrata;Insel, Philip;Curtis, S. McKay;Mungas, Dan;Crane, Paul K.
阿尔茨海默病神经成像计划（ADNI）测量与执行功能（EF）广泛相关的能力，包括WAIS-R数字符号替换、向后数字跨度、轨迹A和B、类别流畅性和时钟绘制。本研究探讨了基于这些多重指标的执行功能测量是否比广泛使用的单个成分具有更好的心理测量特征。我们运用项目反应理论方法对800名ADNI参与者进行了问卷调查，得出了一个综合得分（ADNI-EF）。然后，我们比较了390名轻度认知障碍（MCI）的纵向随访参与者的ADNI-EF和组成测量：(1)检测变化的能力；(2)预测转化为痴呆的能力；(3)与mri衍生的额叶系统相关结构测量的横断面关联强度；(4)与脑脊液（CSF）淀粉样蛋白β1-42、总tau和磷酸化tau181P水平的基线关联强度。随着时间的推移，ADNI-EF表现出最大的变化，其次是类别流畅性。ADNI-EF需要减少40%的样本量来检测变化。ADNI-EF是AD转化的最强预测因子。ADNI-EF是唯一与所有MRI区域显著相关的指标，尽管其他指标在少数区域的相关性更强。ADNI-EF与所有CSF指标相关。ADNI-EF似乎是MCI中有用的EF复合测量，与任何复合部件一样好或更好。本研究展示了一种从常用测试中开发心理测量学上复杂的综合分数的方法。
The Alzheimer’s Disease Neuroimaging Initiative (ADNI) measures abilities broadly related to executive function (EF), including WAIS-R Digit Symbol Substitution, Digit Span Backwards, Trails A and B, Category Fluency, and Clock Drawing. This study investigates whether a composite executive function measure based on these multiple indicators has better psychometric characteristics than the widely used individual components. We applied item response theory methods to 800 ADNI participants to derive an EF composite score (ADNI-EF) from the above measures. We then compared ADNI-EF with component measures in 390 longitudinally-followed participants with mild cognitive impairment (MCI) with respect to: (1) Ability to detect change over time; (2) Ability to predict conversion to dementia; (3) Strength of cross-sectional association with MRI-derived measures of structures involved in frontal systems, and (4) Strength of baseline association with cerebrospinal fluid (CSF) levels of amyloid β1-42, total tau, and phosphorylated tau181P. ADNI-EF showed the greatest change over time, followed closely by Category Fluency. ADNI-EF needed a 40 % smaller sample size to detect change. ADNI-EF was the strongest predictor of AD conversion. ADNI-EF was the only measure significantly associated with all the MRI regions, though other measures were more strongly associated in a few of the regions. ADNI-EF was associated with all the CSF measures. ADNI-EF appears to be a useful composite measure of EF in MCI, as good as or better than any of its composite parts. This study demonstrates an approach to developing a psychometrically sophisticated composite score from commonly-used tests.
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影响因子：
4.2
作者：
Ewers M;Walsh C;Trojanowski JQ;Shaw LM;Petersen RC;Jack CR Jr;Feldman HH;Bokde AL;Alexander GE;Scheltens P;Vellas B;Dubois B;Weiner M;Hampel H;North American Alzheimer's Disease Neuroimaging Initiative (ADNI)
通讯作者：
North American Alzheimer's Disease Neuroimaging Initiative (ADNI)
影响因子：
4.2
作者：
Cardenas, V. A.;Chao, L. L.;Studholme, C.;Yaffe, K.;Miller, B. L.;Madison, C.;Buckley, S. T.;Mungas, D.;Schuff, N.;Weiner, M. W.
通讯作者：
Weiner, M. W.
影响因子：
--
作者：
De Meyer, Geert;Shapiro, Fred;Vanderstichele, Hugo;Vanmechelen, Eugeen;Engelborghs, Sebastiaan;De Deyn, Peter Paul;Coart, Els;Hansson, Oskar;Minthon, Lennart;Zetterberg, Henrik;Blennow, Kaj;Shaw, Leslie;Trojanowski, John Q.
通讯作者：
Trojanowski, John Q.
影响因子：
--
作者：
Gomar, Jesus J.;Bobes-Bascaran, Maria T.;Goldberg, Terry E.
通讯作者：
Goldberg, Terry E.
影响因子：
1.2
作者：
Li, YM;Bolt, DM;Fu, JB
通讯作者：
Fu, JB