The distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease.
The distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease.
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抗肾小球基底膜疾病患者肾组织中IgG亚类沉积的分布。
DOI：
10.1186/1471-2172-14-19
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发表时间：
2013-04-15
期刊：
影响因子：
3
通讯作者：
Zhao MH
中科院分区：
文献类型：
--
作者：
Qu Z;Cui Z;Liu G;Zhao MH
抗肾小球基底膜 (GBM) 疾病的肾损伤定义为 IgG 沿 GBM 线性沉积和快速进展性肾小球肾炎。迄今为止，抗 GBM IgG 亚类在肾组织中的分布仍不清楚。在当前的研究中，我们使用免疫组织化学方法研究了 46 名抗 GBM 疾病患者的肾活检标本中四种 IgG 亚类的沉积情况。所有四种 IgG 亚类均可在 GBM 内检测到。所有患者 (100%) 均检测到抗 GBM IgG3，其中 39 名患者 (84.8%) 表现为弱节段染色，7 名患者 (15.2%) 表现为强线性沉积。 22 例（47.8%）患者检测到抗 GBM IgG2，其中 20 例（90.9%）患者呈弱节段性沉积，2 例（9.1%）患者呈强线性染色。分别在 9 名（19.6%）和 7 名（15.2%）患者中检测到抗 GBM IgG1 和 IgG4。在 31 名 (67.4%) 患者中还检测到沿肾小管基底膜 (TBM) 的 IgG 沉积。其中，IgG亚类分布与GBM内沉积相似：IgG1 6.5%（2/31）、IgG2 45.2%（14/31）、IgG3 100%（31/31）和IgG4 9.7%（3/31）。我们观察到抗 TBM IgG3 沉积增加的患者间质炎症细胞浸润增加 (P=0.031)。抗GBM IgG3主要沿着GBM和TBM沉积在抗GBM疾病患者的肾活检标本上，这可能参与该疾病的肾损伤的发展。
Renal injury of anti-glomerular basement membrane (GBM) disease is defined by the linear deposition of IgG along GBM and rapidly progressive glomerulonephritis. To date, the distribution of anti-GBM IgG subclasses on renal tissue is still unclear. In the current study, we investigated the deposition of the four IgG subclasses using immunohistochemistry in the renal biopsy specimens from 46 patients with anti-GBM disease. All four IgG subclasses can be detected within the GBM. Anti-GBM IgG3 was detected in all patients (100%), with 39 (84.8%) patients presenting with weak segmental staining and 7 (15.2%) patients with strong linear deposition. Anti-GBM IgG2 was detected in 22 (47.8%) patients, with 20 (90.9%) patients having weak segmental deposition and 2 (9.1%) patients presenting strong linear staining. Anti-GBM IgG1 and IgG4 were detected in 9 (19.6%) and 7 (15.2%) patients, respectively. IgG deposition along tubular basement membrane (TBM) was also detected in 31 (67.4%) patients. Among them, the IgG subclass distribution was similar to that of the deposition within the GBM: IgG1 6.5% (2/31), IgG2 45.2% (14/31), IgG3 100% (31/31) and IgG4 9.7% (3/31). We observed increased inflammatory cell infiltration into the interstitium in patients with increased anti-TBM IgG3 deposits (P=0.031). Anti-GBM IgG3 predominantly deposits along GBM and TBM on renal biopsy specimens from patients with anti-GBM disease, which may be involved in the development of renal injury of the disease.
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影响因子：
2.7
作者：
Zhao, Juan;Yan, Yu;Zhao, Ming-Hui
通讯作者：
Zhao, Ming-Hui
影响因子：
4.8
作者：
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通讯作者：
Kalluri, R
影响因子：
4.4
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通讯作者：
Yamamoto, T
影响因子：
2.5
作者：
CATTRAN, DC
通讯作者：
CATTRAN, DC
DOI：
10.1056/nejmoa0910500
发表时间：
2010-07-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
Pedchenko V;Bondar O;Fogo AB;Vanacore R;Voziyan P;Kitching AR;Wieslander J;Kashtan C;Borza DB;Neilson EG;Wilson CB;Hudson BG
通讯作者：
Hudson BG