Early infancy as a critical period for development of obesity and related conditions.
Early infancy as a critical period for development of obesity and related conditions.
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DOI：
10.1159/000281141
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Gillman MW
中科院分区：
文献类型：
--
作者：
Gillman MW
目前的肥胖症流行病甚至影响到我们社会中最年幼的儿童，包括出生后头几个月的儿童。动物实验表明，出生后早期可能对健康能量稳态的发展至关重要，从而预防肥胖。在人类中，观察性研究和随机喂养试验的后续研究表明，婴儿期前半期体重迅速增加预示着后来的肥胖和高血压。尽管结果越来越一致，但在临床或公共卫生影响明确之前，仍有几个问题有待回答。这些包括需要婴儿期的身体组成数据和来自发展中国家的数据，以确定在生命的最初几周内肥胖增加的可改变的决定因素，采取干预措施来改变这些决定因素，检查不同结果的更多与更少快速体重增加的权衡，并以具有成本效益的方式将任何被证明有效的干预措施纳入临床和公共卫生实践。
The current obesity epidemic has affected even the youngest children in our societies, including those in the first months of life. Animal experiments suggest that the early postnatal period may be critical to development of healthful energy homeostasis and thus prevention of obesity. In humans, observational studies and follow-up of randomized feeding trials show that rapid weight gain in the first half of infancy predicts later obesity and higher blood pressure. Despite the mounting consistency of results, several questions remain to be answered before clinical or public health implications are clear. These include the need for body composition data in infancy and data from the developing world to identify modifiable determinants of gain in adiposity in the early weeks of life, to mount interventions to modify these determinants, to examine tradeoffs of more vs. less rapid weight gain for different outcomes, and to incorporate any interventions that prove to be efficacious into clinical and public health practice in a cost-effective manner.
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影响因子：
8
作者：
Belfort MB;Rifas-Shiman SL;Rich-Edwards JW;Kleinman KP;Oken E;Gillman MW
通讯作者：
Gillman MW
影响因子：
158.5
作者：
Barker, DJP;Osmond, C;Eriksson, JG
通讯作者：
Eriksson, JG
影响因子：
5.1
作者：
AGRAS, WS;KRAEMER, HC;HAMMER, LD
通讯作者：
HAMMER, LD
影响因子：
8
作者：
Ehrenkranz, RA;Dusick, AM;Poole, WK
通讯作者：
Poole, WK
影响因子：
5.1
作者：
Belfort, Mandy B.;Rifas-Shiman, Sheryl L.;Gillman, Matthew W.
通讯作者：
Gillman, Matthew W.