Infant growth and child cognition at 3 years of age.
Infant growth and child cognition at 3 years of age.
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DOI：
10.1542/peds.2008-0500
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发表时间：
2008-09
期刊：
影响因子：
8
通讯作者：
Gillman MW
中科院分区：
文献类型：
--
作者：
Belfort MB;Rifas-Shiman SL;Rich-Edwards JW;Kleinman KP;Oken E;Gillman MW
婴儿期是大脑发育的关键时期。在健康人群中，很少有研究研究婴儿体重增加与后来的神经发育结果之间的关系。这项工作的目的是检查婴儿出生到6个月体重增加与3岁儿童认知和视觉运动技能的关系。我们研究了Project Viva中的872名参与者，这是一项持续的前瞻性、纵向、产前队列研究。我们从医疗表中提取了出生体重，并在6个月大的时候称了婴儿的体重。我们使用2000年疾病控制和预防中心的增长图表得出按年龄计算的体重z分数。我们的主要预测指标是婴儿体重增加，定义为6个月时的年龄体重z分数，根据出生时的年龄体重z分数进行调整。在3岁时，我们用皮博迪图画词汇测验III测量了儿童的认知能力，用视觉运动能力大范围评估测量了儿童的视觉运动技能。皮博迪图片词汇测试III的平均分数为104.2，视觉运动能力宽范围评估测试的平均分数为102.8。平均出生体重z得分为0.21，平均6个月体重z得分为0.39。在调整了儿童年龄、性别、胎龄、母乳喂养持续时间、主要语言、种族/民族、母亲年龄、胎次、吸烟状况、认知能力、父母教育程度和收入水平的多元线性回归分析中，我们发现婴儿体重增加与儿童皮博迪图片词汇测试III分数(−每z分数增加0.4点，95%可信区间−1.3，0.6)或视觉运动能力总宽范围评估标准分数(−0.4点，95%可信区间−1.2，0.5)没有关联。在健康的足月出生的3岁儿童中，婴儿体重增加较慢与较差的神经发育结果无关。这些结果应该有助于确定婴儿的最佳生长模式，以平衡整个生命过程中健康结果的风险和好处。
Infancy is a critical period for brain development. Few studies have examined the extent to which infant weight gain is associated with later neurodevelopmental outcomes in healthy populations. The purpose of this work was to examine associations of infant weight gain from birth to 6 months with child cognitive and visual-motor skills at 3 years of age. We studied 872 participants in Project Viva, an ongoing prospective, longitudinal, prebirth cohort. We abstracted birth weight from the medical chart and weighed infants at 6 months of age. We used the 2000 Centers for Disease Control and Prevention growth charts to derive weight-for-age z scores. Our primary predictor was infant weight gain, defined as the weight-for-age z score at 6 months adjusted for the weight-for-age z score at birth. At 3 years of age, we measured child cognition with the Peabody Picture Vocabulary Test III and visual-motor skills with the Wide Range Assessment of Visual Motor Abilities. Mean Peabody Picture Vocabulary Test III score was 104.2, and mean Wide Range Assessment of Visual Motor Abilities test score was 102.8. Mean birth weight z score was 0.21, and mean 6-month weight z score was 0.39. In multiple linear regression adjusted for child age, gender, gestational age, breastfeeding duration, primary language, and race/ethnicity; maternal age, parity, smoking status, and cognition; and parental education and income level, we found no association of infant weight gain with child Peabody Picture Vocabulary Test III score (−0.4 points per z score weight gain increment, 95% confidence interval −1.3, 0.6) or total Wide Range Assessment of Visual Motor Abilities standard score (−0.4 points, 95% confidence interval −1.2, 0.5). Slower infant weight gain was not associated with poorer neurodevelopmental outcomes in healthy, term-born 3-year-old children. These results should aid in determining optimal growth patterns in infants to balance risks and benefits of health outcomes through the life course.
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影响因子：
8
作者：
Emond, Alan M.;Blair, Peter S.;Drewett, Robert F.
通讯作者：
Drewett, Robert F.
影响因子：
8.9
作者：
Monteiro, POA;Victora, CG
通讯作者：
Victora, CG
影响因子：
8
作者：
Ehrenkranz, RA;Dusick, AM;Poole, WK
通讯作者：
Poole, WK
DOI：
10.1016/0002-9378(82)90117-x
发表时间：
1982-01-01
影响因子：
9.8
作者：
HACK, M;MERKATZ, IR;FANAROFF, AA
通讯作者：
FANAROFF, AA
影响因子：
7.1
作者：
HUSAINI, MA;KARYADI, L;POLLITT, E
通讯作者：
POLLITT, E