Relevance of collagen piezoelectricity to "Wolff's Law": a critical review.
Relevance of collagen piezoelectricity to "Wolff's Law": a critical review.
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DOI：
10.1016/j.medengphy.2009.02.006
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发表时间：
2009-09
影响因子：
2.2
通讯作者：
Grodzinsky AJ
中科院分区：
文献类型：
--
作者：
Ahn AC;Grodzinsky AJ
根据“沃尔夫定律”，骨在最大应力的区域沉积和增强。从临床的角度来看，这一“定律”得到了骨密度和体力活动之间强相关性的支持。然而，从机械学的角度来看，该定律对寻求了解骨细胞和成骨细胞如何感知机械负荷的科学家提出了挑战。在20世纪60年代，胶原压电性被认为是一种潜在的机制，通过这种机制，骨细胞可以检测到更大应力的区域，但随着更引人注目的机制（如流动电位）的确定，压电性的重要性降低。此外，越来越多的证据表明，流体相关的剪切应力在骨细胞的机械感觉功能中的作用，使得压电在骨生理学中似乎更加过时。这篇评论批判性地评估了胶原压电性（如果有的话）在沃尔夫定律中的作用-特别是，关于其参与应变产生的电位，现有的替代机制，目前对骨机械感觉的理解，以及压电性是否在这个新提出的机制的背景下发挥有影响力的作用的证据。除了回顾文献，这篇综述产生了几个假设，并提出了未来的研究，以充分解决骨生理学的压电性的相关性。
According to “Wolff’s Law”, bone is deposited and reinforced at areas of greatest stress. From a clinical perspective, this “law” is supported by the strong association between bone density and physical activity. From a mechanistic standpoint, however, the law presents a challenge to scientists seeking to understand how osteocytes and osteoblasts sense the mechanical load. In the 1960’s, collagen piezoelectricity was invoked as a potential mechanism by which osteocytes could detect areas of greater stress but piezoelectricity diminished in importance as more compelling mechanisms, such as streaming potential, were identified. In addition, accumulating evidence for the role of fluid-related shear stress in osteocyte’s mechanosensory function has made piezoelectricity seemingly more obsolete in bone physiology. This review critically evaluates the role of collagen piezoelectricity (if any) in Wolff’s Law – specifically, the evidence regarding its involvement in strain-generated potentials, existing alternate mechanisms, the present understanding of bone mechanosensation, and whether piezoelectricity serves an influential role within the context of this newly proposed mechanism. In addition to reviewing the literature, this review generates several hypotheses and proposes future research to fully address the relevance of piezoelectricity in bone physiology.
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影响因子：
56.9
作者：
BASSETT, CAL;BECKER, RO
通讯作者：
BECKER, RO
DOI：
10.1002/ajpa.20155
发表时间：
2004-01-01
期刊：
YEARBOOK OF PHYSICAL ANTHROPOLOGY, VOL 47
影响因子：
--
作者：
Pearson, Osbjorn M.;Lieberman, Daniel E.
通讯作者：
Lieberman, Daniel E.
影响因子：
64.8
作者：
BASSETT, CA;PAWLUK, RJ;BECKER, RO
通讯作者：
BECKER, RO
DOI：
10.2106/00004623-196648050-00009
发表时间：
1966-01-01
影响因子：
5.3
作者：
FRIEDENBERG, ZB;BRIGHTON, CT
通讯作者：
BRIGHTON, CT
影响因子：
--
作者：
Bromage, Timothy G.;Goldman, Haviva M.;Riggs, Christopher M.
通讯作者：
Riggs, Christopher M.