Immunoregulation by antibody secreting cells in inflammation, infection, and cancer.
Immunoregulation by antibody secreting cells in inflammation, infection, and cancer.
复制标题
炎症、感染和癌症中抗体分泌细胞的免疫调节。
DOI：
10.1111/imr.12991
复制
发表时间：
2021-09
影响因子：
8.7
通讯作者：
Debes GF
中科院分区：
文献类型：
--
作者：
McGettigan SE;Debes GF
抗体分泌细胞（Antibody secreting cells, ASCs）被认为是体液免疫反应的“驮马”，它们不知疲倦地产生大量抗体，在宿主防御、炎症和维持体内平衡中发挥一系列功能。虽然传统上认为主要是衰老细胞，但最近令人惊讶的发现表明，ASCs亚群下调不依赖于抗体形成的持续免疫反应。这些调节性ASCs产生IL-10或IL-35，并参与维持组织和免疫稳态。它们还可以抑制感染、过敏和炎症性疾病中的致病性白细胞，这些疾病会影响组织，如中枢神经系统和呼吸道。此外，调节性ASCs浸润多种癌症类型，限制有效的抗肿瘤T细胞反应。虽然还不完全清楚，但控制ASC分化、B细胞表达IL-10和同时分泌抗体和IL-10的ASC的产生的因素有显著的重叠。在这篇综述中，我们将介绍在病理和稳定状态下各种组织中调节性ASCs的生物学、表型、产生、维持和功能。更好地了解调节性asc的发展及其生物学作用，对于开发用于治疗炎症性疾病、感染和癌症的新型asc靶向疗法至关重要。
Antibody secreting cells (ASCs) are considered work horses of the humoral immune response for their tireless effort to produce large amounts of antibodies that fulfill an array of functions in host defense, inflammation, and maintenance of homeostasis. While traditionally considered largely senescent cells, surprising recent findings demonstrate that subsets of ASCs downmodulate ongoing immune responses independent of antibody formation. Such regulatory ASCs produce IL-10 or IL-35 and are implicated in maintaining tissue and immune homeostasis. They also serve to suppress pathogenic leukocytes in infection, allergy, and inflammatory diseases that affect tissues, such as the central nervous system and the respiratory tract. Additionally, regulatory ASCs infiltrate various cancer types and restrict effective anti-tumor T cell responses. While incompletely understood, there is significant overlap in factors that control ASC differentiation, IL-10 expression by B cells and the generation of ASCs that secrete both antibodies and IL-10. In this review, we will cover the biology, phenotype, generation, maintenance and function of regulatory ASCs in various tissues under pathological and steady states. An improved understanding of the development of regulatory ASCs and their biological roles will be critical for generating novel ASC-targeted therapies for the treatment of inflammatory diseases, infection, and cancer.
登录
查看更多内容
影响因子：
7.3
作者：
Brynjolfsson SF;Persson Berg L;Olsen Ekerhult T;Rimkute I;Wick MJ;Mårtensson IL;Grimsholm O
通讯作者：
Grimsholm O
影响因子：
30.5
作者：
Cretney, Erika;Xin, Annie;Kallies, Axel
通讯作者：
Kallies, Axel
影响因子：
4.4
作者：
Batten, M;Fletcher, C;Mackay, F
通讯作者：
Mackay, F
影响因子：
4.4
作者：
Barnes, Nicholas A.;Stephenson, Sophie;Doody, Gina M.
通讯作者：
Doody, Gina M.
DOI：
10.4049/jimmunol.1001431
发表时间：
2010-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Barr TA;Brown S;Mastroeni P;Gray D
通讯作者：
Gray D