Unexplored therapeutic opportunities in the human genome.
Unexplored therapeutic opportunities in the human genome.
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DOI：
10.1038/nrd.2018.14
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Zahoránszky-Köhalmi G
中科院分区：
文献类型：
--
作者：
Oprea TI;Bologa CG;Brunak S;Campbell A;Gan GN;Gaulton A;Gomez SM;Guha R;Hersey A;Holmes J;Jadhav A;Jensen LJ;Johnson GL;Karlson A;Leach AR;Ma'ayan A;Malovannaya A;Mani S;Mathias SL;McManus MT;Meehan TF;von Mering C;Muthas D;Nguyen DT;Overington JP;Papadatos G;Qin J;Reich C;Roth BL;Schürer SC;Simeonov A;Sklar LA;Southall N;Tomita S;Tudose I;Ursu O;Vidovic D;Waller A;Westergaard D;Yang JJ;Zahoránszky-Köhalmi G
很大一部分生物医学研究和治疗学的发展都集中在人类基因组的一小部分上。为了绘制人类基因组编码蛋白质周围的知识缺口，并促进探索目前研究不足但潜在可药物的蛋白质，美国国立卫生研究院于2014年发起了照亮可药物基因组(IDG)倡议。在这篇文章中，我们讨论了IDG知识管理中心对广泛的基因组、蛋白质组、化学和疾病相关资源数据的系统收集和处理如何使基于证据的标准得以发展，以跟踪人类蛋白质的目标发育水平(TDL)，这表明人类蛋白质组中大约三分之一的蛋白质存在严重的知识缺陷。然后，我们介绍了TDL类别以及关键的药物靶标类别，包括G蛋白偶联受体、蛋白激酶和离子通道，这说明了生物医学研究和治疗开发的未探索机会的性质。
A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative in 2014. In this article, we discuss how the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins, which indicates a substantial knowledge deficit for approximately one out of three proteins in the human proteome. We then present spotlights on the TDL categories as well as key drug target classes, including G protein-coupled receptors, protein kinases and ion channels, which illustrate the nature of the unexplored opportunities for biomedical research and therapeutic development.
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遗传对人体组织基因表达的影响。
影响因子：
64.8
作者：
GTEx Consortium;Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group;Statistical Methods groups—Analysis Working Group;Enhancing GTEx (eGTEx) groups;NIH Common Fund;NIH/NCI;NIH/NHGRI;NIH/NIMH;NIH/NIDA;Biospecimen Collection Source Site—NDRI;Biospecimen Collection Source Site—RPCI;Biospecimen Core Resource—VARI;Brain Bank Repository—University of Miami Brain Endowment Bank;Leidos Biomedical—Project Management;ELSI Study;Genome Browser Data Integration &Visualization—EBI;Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz;Lead analysts:;Laboratory, Data Analysis &Coordinating Center (LDACC):;NIH program management:;Biospecimen collection:;Pathology:;eQTL manuscript working group:;Battle A;Brown CD;Engelhardt BE;Montgomery SB
通讯作者：
Montgomery SB
影响因子：
14.9
作者：
Nguyen DT;Mathias S;Bologa C;Brunak S;Fernandez N;Gaulton A;Hersey A;Holmes J;Jensen LJ;Karlsson A;Liu G;Ma'ayan A;Mandava G;Mani S;Mehta S;Overington J;Patel J;Rouillard AD;Schürer S;Sheils T;Simeonov A;Sklar LA;Southall N;Ursu O;Vidovic D;Waller A;Yang J;Jadhav A;Oprea TI;Guha R
通讯作者：
Guha R
影响因子：
7.7
作者：
Gloyn, AL;Weedon, MN;Frayling, TM
通讯作者：
Frayling, TM
影响因子：
56.9
作者：
Campillos, Monica;Kuhn, Michael;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
10.6
作者：
Berman, RM;Cappiello, A;Krystal, JH
通讯作者：
Krystal, JH